The first case is described in Wuhan city of China in December 2019 and the disease (COVID-19) continues to pose threat to global health all over the world affecting more than approximately 476 million confirmed cases and 6 million deaths. Reliable and effective methods are taken a critical role such as real-time reverse transcriptase (RT)-PCR test as a gold standard method, serological tests, and reverse transcriptase loopmediated isothermal amplification (RT-LAMP) method is chosen firstly. However, an actual important problem is the detection of SARS-CoV-2 mutations. Nowadays, there are many mutation types is described for the SARS-CoV-2 including D614G, N501Y, E484K, or L452R. Herein, we comprehensively review COVID-19 disease diagnosis and types of mutation from yesterday to today to contribute to the literature on the global pandemic that affects the world.
SARS-CoV-2, Variants, Mutation, Diagnostic