Original Research Open Access
Volume 1 | Issue 1 | DOI: https://doi.org/10.33696/immunology.1.003

Progression of Autoantibodies Anti-Gad and Anti-IA2 in Type 1A Diabetics Aged 5 to 21 Years in Cote d’Ivoire

  • 1National Public Health Institute, Abidjan, P.O. BOX 47 Abidjan, Côte d’Ivoire
  • 2Diabetes Clinic, University Hospital Center (U.H.C) of Treichville, Côte d’Ivoire
  • 3Diabetology and Endocrinology Department, University Hospital Center (U.H.C) of Yopougon, Côte d’Ivoire
  • 4Laboratory of Immunology, Hospital Habib Bourguiba of Sfax, 3029Sfax, Tunisia
  • 5Laboratory of Biochemistry-Pharmacodynamics, Faculty of Biosciences, Felix Houphouët Boigny University, P.O BOX 582 Abidjan 22, Côte d’Ivoire
+ Affiliations - Affiliations

Corresponding Author

Dr. Trébissou Aïssé Florence Judith, aisse.judith@gmail.com

Received Date: July 18, 2019

Accepted Date: July 29, 2019


Background: Diabetes autoantibodies are indispensable markers of diabetes classification.

Objective: To research autoantibodies anti-GAD and anti-IA2 in type 1A diabetics (T1D) aged 5 to 21 years, and to follow the progression of these autoantibodies in T1D patients, in Côte d’Ivoire.

Methods: The study population composed of 28 T1D patients, aged 5 to 21 years. T1D were followed up in two diabetes care centers in Abidjan district, Endocrinology departments of U.H.C of Yopougon and Treichville. Anti-GAD and anti-IA2 autoantibodies were researched by ELISA.

Results: Anti-GAD and anti-IA2 were present in T1D. After 2 years of diabetes, the titer of the anti-GAD autoantibodies increased to the mean value of 677.10 ± 353.20 IU/ml. Then, a fall of the anti-GAD autoantibodies until the cancellation was observed from the 8th to the 9th with values of 117 IU/ml to 10.14 IU/ml. Anti-IA2 autoantibodies fall at 9th year of diabetes with a value of 55.10 IU/ml.

Conclusion: Anti-GAD and anti-IA2 autoantibodies persist after 9 years of diabetes, causing total destruction over time of the pancreatic  β-cell mass in patients from Côte d’Ivoire, leading them to the death.


Diabetes autoantibodies, Type 1A diabetes, Côte d’Ivoire

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