Research Article Open Access
Volume 2 | Issue 2 | DOI: https://doi.org/10.33696/cancerimmunol.2.015

Involvement of D-Loop Mutations in the Occurrence of Ovarian Carcinoma

  • 1Team of Genetics for Population, Department of Animal Biology, Faculty of Science and Technology, Cheikh Anta Diop University of Dakar, BP. 5005, Senegal
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Corresponding Author

Fatimata Mbaye, fatimata.mbaye@ucad.edu.sn

Received Date: April 09, 2020

Accepted Date: May 19, 2020


Cancer mortality is proportionally higher in Africa than elsewhere in the world. In Senegal, ovarian cancer is responsible for 2.8% of deaths and is one of the most fatal gynaecological cancers. This work is therefore being carried out in order to better understand the impact of D-Loop mutations in the evolution of ovarian cancer in Senegalese women. The genetic variability of D-Loop was studied by PCR-Sequencing, in thirty-eight (38) patients. The results revealed twenty-two (22) mutations. In this study, eleven (11) mutations (A66G, C186T, G309A, C388T, C418T, G421T, C422A, A425C, A425G, C431T and G499A) were identified as somatic mutations in ovarian cancer. All the variants are present in the Mitomap database. A variation (19.05%) in the length of the first section of the D310 area was found. The results obtained in this study show that the D310 region of the D-Loop is not the “hot spot” for mtDNA mutations in ovarian cancer in Senegalese women.


Cancer, Ovary, Displacement Loop, Mutations

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