Commentary Open Access
Volume 2 | Issue 6 | DOI: https://doi.org/10.33696/immunology.2.055

Influenza A Virus Infection Induces White Adipose Tissue Browning: A Metabolic Adaptation to Infection?

  • 1Univ. Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille (CIIL), Lille, France
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Corresponding Author

Isabelle Wolowczuk, isabelle.wolowczuk@pasteur-lille.fr

Received Date: July 29, 2020

Accepted Date: September 08, 2020


We recently reported that influenza infection is associated with drastic, depot-specific changes in white adipose tissue (WAT), notably the occurrence of thermogenic brown-like adipocytes within the subcutaneous depot, a process referred to as WAT browning. In mammals, induction of the thermogenic circuit increases heat production and consumes energy, consequently improving host’s metabolism. Importantly, we also demonstrated that mouse and human preadipocytes commit to the thermogenic differentiation program upon in vitro influenza virus infection; this signifies that infection-associated WAT browning may partly rely on a direct effect of the virus on fat.

Herein, after a short review of the physiological and cellular mechanisms that have been described to regulate WAT browning, including immune-cell-dependent ones, we will comment on the role that white adipose tissue, which is at the crossroads of metabolism and immunity, may play in influenza pathophysiology.


Adipose tissue, Browning, Influenza A virus

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