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Journal of AIDS and HIV Treatment

ISSN: 2688-7436

Original Research Open Access
Volume 7 | Issue 1 | DOI: https://doi.org/10.33696/AIDS.7.062

Epidemiological, Clinical, Therapeutic and Evolutionary Profile of HIV-infected Patients Monitored at the Center of Excellence of the University of Lubumbashi

Philomène Lungu Anzwal1,2, Dodo Manda Mukendi2, Odon Panshi Wa Panshi2, Athy Kalumba Kambote1,3, Nathalie Mbuyamba Mutombo2, Astrid Lokotshe Kanyama2, Jirène Ndibu Ebondo2, Salvatrice Masonga Madika2, Franck Kasans Tshinyengo2, Julie Ilunga2, Mbelu Dina2, Gloria Malitele Babile2, Guy Kandja Lwamba2, Eric Ngindu Mankoy2, Odile Latshupanda Ampeng2, Elie Kabika Yatambo2, David Elo Lombe2, Djo Banza Monga2, Laurent Shamashanga Kwete5, Jérôme Nyembo Lukamba2, Tony Kayembe Kitenge4
  • 1Department of Biomedical Sciences, Faculty of Medicine, University of Lubumbashi, Democratic Republic of Congo
  • 2Center of Excellence for the Care of People Living with HIV/AIDS, Faculty of Medicine, University of Lubumbashi, Democratic Republic of Congo
  • 3Laboratory of the University Clinics of Lubumbashi, Faculty of Medicine, University of Lubumbashi, Democratic Republic of Congo
  • 4Biomedical Sciences, Higher Institute of Medical Techniques of Lubumbashi, Democratic Republic of Congo
  • 5Faculty of Pharmaceutical Sciences, Department of Clinical Biology, University of Lubumbashi, Democratic Republic of Congo
+ Affiliations - Affiliations

Corresponding Author

Philomène Lungu Anzwal, lunguanzwal@gmail.com

Received Date: February 18, 2025

Accepted Date: June 02, 2025

Citation:

Lungu Anzwal P, Manda Mukendi D, Panshi Wa Panshi O, Kalumba Kambote A, Mbuyamba Mutombo N , Lokotshe Kanyama A, et al. Epidemiological, Clinical, Therapeutic and Evolutionary Profile of HIV-infected Patients Monitored at the Center of Excellence of the University of Lubumbashi. J AIDS HIV Treat. 2025;7(1):65-73.


Copyright: © 2025 Lungu Anzwal P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Introduction: HIV infection is characterized by the progressive destruction of CD4+ T lymphocytes, responsible for an immune deficiency, thus promoting the development of serious opportunistic infections and tumors. 

Aim: The objective of this study was to describe the epidemiological, clinical, therapeutic, and disease progression of HIV-infected patients registered and monitored at the Center of Excellence at the University of Lubumbashi.

Methods: Retrospective descriptive study, carried out from 2006 to 2024 using patient records registered at the Center of Excellence. Data were collected using a previously established survey form. Variables collected: socio-demographic variables, opportunistic infections, stages of infection, antiretrovirals, treatment-related complications, mode of HIV transmission, and treatment progress. Data analysis was performed using SPSS 30.0 software. We calculated position and dispersion parameters.

Results: We collected 8,912 cases of HIV infection (24.95%) from a sample of 35,716 patients screened, including 5,271 women (59.1%) and 3,641 men (40.9%). The mean age was 35 ± 0.3 years. Opportunistic infections were dominated by pulmonary (31%) and extrapulmonary (8.8%) tuberculosis, digestive candidiasis (32.5%), cerebral toxoplasmosis (14.9%), isosporiasis (7.4%), herpes simplex (3.1%), cryptococcal meningitis (3.9%), vaginal candidiasis (3.7%), prurigo (3.3%), shingles (2.3%), Kaposi's sarcoma (2.2%), and diarrhea without isolated germs (2.1%). 99.6% of patients were receiving first-line treatment: tenofovir, lamivudine, and dolutegravir. The progression was marked by a death rate of 19.11%, significantly related to infections (p<0.02).

Conclusion: Despite awareness campaigns and the availability and free provision of antiretrovirals, the mortality rate and HIV prevalence remain high in Lubumbashi.

Keywords

Epidemiological, Clinical, therapeutic, and progression profile, PLHIV, Center of Excellence, Lubumbashi

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