Review Article Open Access
Volume 2 | Issue 4 | DOI: https://doi.org/10.33696/cancerimmunol.2.031

Emerging Strategies to Attack Polyploid Cancer Cells

  • 1Anticancer Bioscience, Ltd., and the J. Michael Bishop Institute of Cancer Research, Chengdu, China 640000
  • 2Chengdu University of Traditional Chinese Medicine, 1166 Liutai Avenue, Wenjiang District, Chengdu, China 611137
+ Affiliations - Affiliations

Corresponding Author

Thaddeus D. Allen, thaddeus.allen@mbicr.org

Received Date: October 23, 2020

Accepted Date: November 12, 2020


Polyploid cancer cells can arise de novo in tumors or they can be induced by therapeutics that inadvertently increase the rate of cytokinetic failure. These cells portend a poor outcome in many cancers because polyploid cancer cells can undergo error prone reductive cell divisions to yield aneuploid progeny. The immune system has evolved mechanisms by which it can specifically recognize and remove polyploid cancer cells, but these appear to be tampered with malignancy so that polyploid cells can persist and fuel the development of cancer cell clones that are resistant to therapeutics and have metastatic potential. Here we review mechanisms by which polyploid cancer cells can arise, are surveilled by the immune system and therapeutic strategies that might prevent or directly attack polyploid cancer cells.


Polyploid, Mitosis, Therapeutics, Apoptosis, Cancer, Immune surveillance

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