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Journal of Nanotechnology and Nanomaterials

ISSN: 2692-630X

Commentary Open Access
Volume 6 | Issue 1 | DOI: https://doi.org/10.33696/Nanotechnol.6.060

Comment on “Cholesterol Induced Asymmetry in DOPC Bilayers Probed by AFM Force Spectroscopy”

Dhruva Bhat1, Appala Venkata Ramana Murthy1,*
  • 1Defence Institute of Advanced Technology, DIAT, Pune
+ Affiliations - Affiliations

Corresponding Author

Appala Venkata Ramana Murthy, avrmurthy@diat.ac.in

Received Date: February 06, 2025

Accepted Date: April 24, 2025

Citation:

Bhat D, Murthy AVR. Comment on the Paper “Cholesterol Induced Asymmetry in DOPC Bilayers Probed by AFM Force Spectroscopy”. J Nanotechnol Nanomaterials. 2025;6(1):26-27.


Copyright: © 2025 Bhat D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

In the recent article, Adhyapak et al., used Atomic Force Microscopy (AFM) and Force Spectroscopy to investigate the influence of cholesterol on the phase state behaviour of fluid phase DOPC membranes and found that the excess cholesterol conditions (above 20%) can induce an asymmetry in the lipid bilayer leading to changes both topography and more significantly in the nanomechanical properties of the lipid bilayer.

Keywords

Atomic Force Microscopy, Force Spectroscopy, Phase State Behavior, Asymmetry, Lipid bilayer

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Comment on “Cholesterol Induced Asymmetry in DOPC Bilayers Probed by AFM Force Spectroscopy”

In the recent article, Adhyapak et al., used Atomic Force Microscopy (AFM) and Force Spectroscopy to investigate the influence of cholesterol on the phase state behaviour of fluid phase DOPC membranes and found that the excess cholesterol conditions (above 20%) can induce an asymmetry in the lipid bilayer leading to changes both topography and more significantly in the nanomechanical properties of the lipid bilayer.

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