Nanomaterials with unique size and integrated features allow novel mechanisms for cancer therapy, so nanomedicine offers more possibilities for effective and safe cancer treatment. However, inefficient tumor delivery remains a major challenge in the clinic. In this commentary, we first discuss new designs of nanomedicine to increase tumor accumulation by active targeting strategies. Nanomedicine can be used to improve active targeting via ligand-receptor binding, cell penetration, or specific cell membrane coating, leading to improved therapeutic efficacy and reduced systemic toxicity. In addition, immune cells aredemonstrated as an important component in tumors, and play a critical role in tumor progression and metastasis, here we address tumor-targeting nanomedicine provide unique approaches to remodel the immunosuppressive tumor microenvironment and promote antitumor immune responses.