The published study Compliance and health consequences of menopausal hormonal therapy after surgical menopause: A retrospective study in Thailand showed that menopausal hormonal therapy soon after bilateral oophorectomy before the age of natural menopause in Thailand possibly prevented subsequent osteopenia compared with menopausal hormonal therapy non-users, also without significant adverse breast outcomes comparing between hormonal therapy users and non-users. According to that study, additional data showed that the number of early hormonal users (initiated before age 45 years) who continued hormonal therapy until at least 50 years old (average natural menopausal age in Thailand) is less than that of late hormonal users (initiated at age =45 years). Therefore, hormonal replacement therapy after bilateral oophorectomy before the age of natural menopause, in the absence of contraindication, should be commenced soon at any age after surgery and maintained until at least the age of natural menopause to prevent possible long-term adverse health outcomes from early estrogen deprivation.

Surgical menopause, Menopausal hormonal therapy, Health consequences