Review Article Open Access
Volume 4 | Issue 1 | DOI: https://doi.org/10.33696/haematology.4.053

A Rare Blood Malignancy in a Genetic Hematological Disorder: Polycythemia Vera (PV) in Sickle Cell Disease (SCD)

  • 1Debra O. Parker Research Incubator, North Carolina Central University, NC, USA
  • 2Psychoneuroendocrine Rare Diseases Laboratory, North Carolina Central University, NC, USA
  • 3Psychophysiology and Cardiovascular Health Laboratory, North Carolina Central University, NC, USA
  • 4Community Health Psychology Laboratory, North Carolina Central University, NC, USA
  • 5Clinical Psychology Program, Fielding Graduate University, CA, USA
  • 6Bridges Point Sickle Cell Foundation, NC, USA
  • 7Maya Angelou Center for Health Equity, Wake Forest Medical Center, NC, USA
  • 8Social Sciences and Health Policy, Wake Forest Medical Center, NC, USA
  • 9School of Law, North Carolina Central University, NC, USA
  • 10School of Public Health, Johns Hopkins University, MD, USA
  • 11University of Nevada, Las Vegas, NV, USA
  • 12Winston Salem State University, NC, USA
  • 13Duke University Medical Center, NC, USA
  • 14California Northstate University, CA, USA
  • 15Rochester Institute of Technology, NY, USA
+ Affiliations - Affiliations

Corresponding Author

Dr. Christopher L. Edwards, cedwards@nccu.edu

Received Date: July 13, 2023

Accepted Date: August 07, 2023


Objective: To delineate the etiology, symptomatology, and treatment of Polycythemia Vera in adults with Sickle Cell Disease. The current review contains a review of the 4 case reports that we found on the topic. To our knowledge, no other case reports exist.

Methods: We reviewed the scientific literature to discover case reports that included the topic of PV. We noted consistencies in presentation, evaluation, treatment, and clinical outcomes.

Results: We reviewed 4 case reports and a limited number of clinical papers on PV in SCD. We found and reported on consistencies in clinical presentation and the diversity of treatments. We reported hematological, bone marrow, and radiographic findings.

Conclusions: There is great variability in the evaluation and treatment of cases of PV in SCD. We advocate for more research and deconstructing the complicated relationship between these two comorbid disorders.


Polycythemia Vera, Sickle Cell Disease, Case reports

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