Review Article Open Access
Volume 2 | Issue 2 | DOI: https://doi.org/10.33696/Gynaecology.2.014

Challenges Regarding the Management of Gynecological and Obstetric Complications in Women with Inherited Factor XIII Deficiency

  • 1Hospices Civils de Lyon, Service de Gynécologie Obstétrique, Hôpital de la Croix-Rousse, France.
  • 2Hospices Civils de Lyon, Unité Hémostase Clinique, Hôpital Louis Pradel, Hospices Civils de Lyon, Bron, France.
+ Affiliations - Affiliations

Corresponding Author

Lucia Rugeri, lucia.rugeri@chu-lyon.fr

Received Date: May 06, 2021

Accepted Date: July 19, 2021


Women with rare bleeding disorders (RBDs) can be exposed throughout their life to several complications such as menorrhagia or hemorrhagic complications during pregnancies and deliveries. Among RBDs, factor XIII deficiency leads to life-threatening hemorrhages such as intracranial hemorrhage, and women during their reproductive period may experience gynecological and obstetric complications, and more specifically recurrent miscarriages due to the role of FXIII in placenta attachment. Because of the rarity of the disease, recommendations for the treatment are mainly based on expert consensus, and although the effectiveness of as-early-as-possible FXIII prophylaxis administration is largely recognized to prevent recurrent miscarriages, the dosage of this prophylaxis is still debated.


Inherited factor XIII deficiency; Menorrhagia; Miscarriages; Pregnancy outcome

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