Archives of Pharmacology and Therapeutics

Commentary Open Access

Single-Case Intervention Research in the Health Sciences: Randomization + Replication = Respectability (Almost)

Joel R. Levin , Thomas R. Kratochwill

Elaboration and extensions are provided of an earlier article on the application of time-series-based single-case intervention designs (SCIDs) and analyses for researchers in the health sciences. The research potential, as well as the strengths and weaknesses of such designs, are detailed.

Arch Pharmacol Ther, 2026, Volume 8, Issue 1, p1-5 | DOI: 10.33696/Pharmacol.8.067

Systematic review Open Access

Safety and Efficacy Outcomes of Oral Nimesulide Use as a Nonsteroidal Anti-Inflammatory Drug in Older Adults: A Comprehensive Systematic Review

Mansij Biswas , Anil Jain , Prince Bakshi

Nimesulide, a preferential Cyclooxygenase-2 (COX-2) inhibitor, is frequently prescribed for musculoskeletal conditions in middle-aged (45–64 years) and older adults (≥65 years). Given age-associated alterations in drug metabolism, polypharmacy, and comorbidities, its safety and efficacy in adults >45 years warrants critical re-evaluation.

Arch Pharmacol Ther, 2026, Volume 8, Issue 1, p6-27 | DOI: 10.33696/Pharmacol.8.068