Archives of Pharmacology and Therapeutics

Commentary Open Access

Single-Case Intervention Research in the Health Sciences: Randomization + Replication = Respectability (Almost)

Joel R. Levin , Thomas R. Kratochwill

Elaboration and extensions are provided of an earlier article on the application of time-series-based single-case intervention designs (SCIDs) and analyses for researchers in the health sciences. The research potential, as well as the strengths and weaknesses of such designs, are detailed.

Arch Pharmacol Ther, 2026, Volume 8, Issue 1, p1-5 | DOI: 10.33696/Pharmacol.8.067

Systematic review Open Access

Safety and Efficacy Outcomes of Oral Nimesulide Use as a Nonsteroidal Anti-Inflammatory Drug in Older Adults: A Comprehensive Systematic Review

Mansij Biswas , Anil Jain , Prince Bakshi

Nimesulide, a preferential Cyclooxygenase-2 (COX-2) inhibitor, is frequently prescribed for musculoskeletal conditions in middle-aged (45–64 years) and older adults (≥65 years). Given age-associated alterations in drug metabolism, polypharmacy, and comorbidities, its safety and efficacy in adults >45 years warrants critical re-evaluation.

Arch Pharmacol Ther, 2026, Volume 8, Issue 1, p6-27 | DOI: 10.33696/Pharmacol.8.068

Editorial Open Access

POSTCOVID-19 WAR Era, Different Pharmacotoxicologic (Re)Actions Updates, Toxic Synergies, and How Drug Abuse Exacerbates Burdens

Bahram Alamdary Badlou

Recently it became obvious that drug abuse, infectious disease, and hematologic dysregulation are not peripheral concerns—they are central determinants of therapeutic success or failure. Late-stage metastatic cancer remains one of the most pharmacologically unforgiving landscapes in modern medicine. Despite decades of therapeutic innovation, the microenvironments that support disseminated tumor cells have evolved into highly specialized, treatment-resistant ecosystems.

Arch Pharmacol Ther, 2026, Volume 8, Issue 1, p31-33 | DOI: 10.33696/Pharmacol.8.070

Editorial Open Access

Doctor-Patient Relationship Tools to Improve the Pharmacological Prescription Process

Jose Luis Turabian

The doctor-patient relationship is fundamental for both diagnosis and treatment. All healthcare activity is influenced, directly or indirectly, by interpersonal relationships. Communication allows for the integration of clinical reasoning by connecting the biomedical and psychosocial aspects of clinical care. It is about integrating communication and clinical reasoning, and connecting the biomedical and psychosocial aspects of clinical care.

Arch Pharmacol Ther, 2026, Volume 8, Issue 1, p28-30 | DOI: 10.33696/Pharmacol.8.069