Institute of Nuclear Medicine and Allied Sciences (DRDO)
Development of the radioprotector has been the prime focused area of Reaserch at INMAS since of its establishment. Despite several serious efforts in the past not a single radioprotective molecule has been approved for emergency use so far not only in India but anywhere in the world. We have achieved a major milestone in the area of radiation countermeasure development in the past years. Based on the scientific leads that achieved in the last INM-311 project, to translate and complete the regulatory studies further work was undertaken under Rakshak programme.First of all a process of chemical synthesis of one of the potential novel molecules i.e. N acetyl L tryptophan glucoside was developed and the product of the chemical synthesis was purified and characterized using HNMR, CNMR, LC-MS, FTIR, EPR, and spectroscopic analytical techniques.. A method to quantify the yield of the chemical synthesis was also developed. The radioprotective efficacy of chemiccaly synthesized NATG was established in the mice model. Though the process of chemical synthesis was optimized however, due to requirement of NATG in high quantity with CAO certification for further regulatory study like pharmacokinetics and toxicity, NAT the second equally efficacious radioprotective molecules identified by NIPER Chandigarh in bacterial fractions was given top priority for further development.
Scientific Archives is a global publisher initiated with the mission of ensuring equal opportunity for accessing science to research community all over the world. Spreading research findings with great relevance to all channels without any barrier is our goal. We want to overcome the challenges of Open Access with ensured quality and transparency.