Zachary+A+Colon | Scientific Archives

AUTHOR INFO

Zachary A Colon

Interdisciplinary Program in Neuroscience, Georgetown University School of Medicine, Washington, DC, USA

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Commentary Open Access

Glial Cell and Perineuronal Net Interactions in the Dorsal Striatum of Aged Mice

Alejandro Gamboa , Kathleen A Maguire-Zeiss , Scott Litwiler , Zachary A Colon

Elucidating how normal aging increases vulnerability to neurodegeneration remains a major gap in our understanding of disease risk and progression. The dorsal striatum serves as the primary input nucleus of the basal ganglia and is a key region implicated in multiple neurodegenerative diseases (NDDs). In Colon et al. 2025, we examined the impact of normal aging on neuroinflammatory signaling and perineuronal net (PNN) homeostasis within the dorsal striatum.

J Exp Neurol, 7, 2, p55-62

Co Authors

Alejandro Gamboa Georgetown University School of Medicine, Department of Neuroscience, Georgetown University School of Medicine, Washington, DC, USA View Profile

Kathleen A Maguire-Zeiss Georgetown University School of Medicine, Interdisciplinary Program in Neuroscience, Georgetown University School of Medicine, Washington, DC, USA View Profile

Scott Litwiler Georgetown University School of Medicine, Department of Neuroscience, Georgetown University School of Medicine, Washington, DC, USA View Profile

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