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AUTHOR INFO

Akane Sato

Department of Biology, Waseda University, Tokyo, Japan


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Mini Review Open Access

GRP78: A Multifaceted Role in Cancer Progression and Infectious Disease Transmission

Akane Sato , Etsuro Ito

The 78-kDa glucose-regulated protein GRP78, also known as HSPA5 or BiP, is a heat shock protein 70 family member that promotes functions of the endoplasmic reticulum, such as protein folding and assembly, prevention of aggregation of misfolded proteins, translocation of secreted proteins, and initiation of the unfolded protein response. GRP78 may also be a cancer marker. When small extracellular vesicles containing GRP78 are released from cancer cells, recipient cells exhibit enhanced malignant progression and angiogenesis.

J Cell Immunol, 2025, Volume 7, Issue 1, p9-13 | DOI: 10.33696/immunology.7.217
Co Authors
Etsuro Ito Waseda University, Department of Biology, Waseda University, Shinjuku, Tokyo 162-8480, Japan View Profile

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