Ketamine has long been used in the field of anesthesia [1]. Its rapid and long-acting analgesic effects associated with its dissociative properties have also established its use in prehospital and emergency department patients.

Addiction is defined as being a primary chronic disease of the brain reward, motivation, and memory in this complex circuitry. A dysfunction in this complex circuitry can lead to certain manifestations in an individual [1]. The individual who suffers from addiction does not have the ability to abstain from this harmful pursuit and, as a result,

Diabetes is a chronic disorder that affects more than 500 million individuals worldwide. It is a life-long disease with complications that attack nearly all other systems within the body. Although there is a slight increase in the prevalence of diabetes in males, ocular surface complications are equally present in males and females.

The research article entitled “Electroacupuncture (EA) attenuates ketamine-induced neuronal injury in the locus coeruleus of rats through modulation of the CAMK II/CREB pathway” makes a substantial contribution to our comprehension of the neuroprotective effects associated with EA. In this commentary, our objective is to intricately expand upon the discourse initiated by the focal article, scrutinizing recent advancements in the field and subjecting pivotal issues to critical analysis.