Pancreatic cancer is a very aggressive disease with high mortality rate and its high mortality rate makes its diagnosis difficult, especially when disease is at an advanced stage. Lack of efficient biomarkers until today makes its diagnosis difficult at early stages and during its progression. Methylation in the promoter of circulatory DNA, cirDNA of tumor suppressive genes is one of the important epigenetic phenomenon contributes to the pathogenesis of diseases and also opening a new venue for the discovery of non-invasive biomarkers. CirDNA methylation signatures represented an important paradigm shift in precision medicine and enabling early detection and monitoring the progression of pancreatic diseases. In this review we will provide an overview of differential methylation levels in PDAC with diagnostic and prognostic potential at the early stages of diseases.

Pancreatic cancer, Circulatory DNA, Non-invasive biomarker, Epigenetic signature, Diagnosis, Prognosis