Journal of Clinical Haematology

Research Article Open Access

Making a Rationale Decision About -Uses of FFP: A Study at the Blood Bank of Tertiary Care Hospital of Southern Rajasthan

Diksha Rewal , Sanjay Prakash , Rajaram Sharma

Blood is a crucial part of life as there is no other alternative to the human body’s connective tissue. Blood is composed of blood cells suspended in plasma. Plasma, which constitutes 55% of body fluid, is mostly water (92% by volume) and contains proteins, glucose, mineral ions, hormones, carbon dioxide, urea, uric acid, oxygen, etc. (plasma being the primary medium for excretory product transportation). Plasma performs many essential functions within the body, like coagulation, supply of nutrients, removal of wastes

Commentary Open Access

Targeting ANP32A Is a Novel Strategy Against Leukemia

Manman Wang , Zan Huang

Acute myeloid leukemia (AML) is a type of hematological malignancies that originate from hematopoietic stem/ progenitor cells in myeloid lineage. The genetic heterogeneity of AML causes varied responses to the existing treatment options, as well as drug resistance and refractory/ recurrent, posing a challenge to personalized precision medicine. Therefore, it is urgent to identify novel molecular targets, discover patient specific and disease specific risk factors, and explore effective combinations of modalities and drugs in the foreseeable future.

Case Report Open Access

B-cell Acute Lymphoblastic Leukemia with a Normal Platelet Count, Presenting as a Limp in a 2-year-old Child

P.M.A.S Senevirathna , K.D.J.M.K Galahitiyawa , D.M.N.K Dassanayake , N.K.K.S Thabrew

Limping in children is a common complaint made at pediatric, pediatric orthopedic and in emergency departments. It is defined as a deviation from the normal gait pattern expected for the child’s age.  Especially in young children, the ambiguities in the signs and symptoms necessitate extensive investigations to enable a reliable medical assessment for the etiological dilemma of limping.

Case Series Open Access

Multiple Myeloma with Neutrophilia: Two Etiologic Pathways for a Rare Presentation of a Common Diagnosis

Rachel Rose Hall , Christine MG Schammel , Jennifer Bell Knight

Multiple myeloma (MM) is a common hematologic malignancy, with 32,110 new cases diagnosed in the United States in 2019, resulting in 12,960 deaths. While neutrophilia
is also a common entity, it most often arises secondary to other etiologies, such as infection or inflammatory processes. 

Case Report Open Access

Concomitant Langerhans Cell Histiocytosis and Chronic Myelomonocytic Leukaemia Responding to 5-azacitidine

Peter Brændstrup , Dennis Lund Hansen , Louise Kristensen , Henrik Frederiksen , Hanne E. H. Møller

Langerhans cell histiocytosis (LCH) is a rare, clonal, haematological disease of myeloid origin involving infiltration of neoplastic cells resembling Langerhans cells in various tissues. LCH cells express normal Langerhans cell markers such as CD1a, Langerin (CD207), and S100.

Research Article Open Access

Safety and Tolerability of Nilotinib in Patients with Chronic Myeloid Leukemia during Routine Clinical Practice: Results from the ERASER Study from Greece

Argiris Symeonidis , Achilles Anagnostopoulos , Maria Ximeri , Georgia Kaiafa , Eleni Kapsali , Nora Athina Viniou , Theodoros Marinakis , Dimitrios Karakasis , Vasiliki Pappa , George Vassilopoulos , Dimitrios Margaritis , Maria Tabitsika , Maria Dimou

Chronic myeloid leukemia (CML) is characterized by the presence of Philadelphia chromosome (Ph+) in the majority of cases, and definitely by the presence of the hybrid BCR/ ABL1 proto-oncogene in all the patients. The BCR::ABL1 fusion gene encodes for an oncoprotein that has an activated tyrosine kinase domain in the ABL region and affects crucial cellular activities, such as increased proliferation, loss of stromal adhesion, and resistance to apoptosis, through enhanced tyrosine phosphorylation of various cellular substrates.