Journal of Clinical Haematology

Original Research Open Access

HiDAC Consolidation Cycles May Impede Stem Cell Transplant Planning for High-Risk Acute Myeloid Leukemia Patients

Michael Stokes , Mohammad Mian , Anvay Shah , Yazmin Reategui-Almonacid , Isabela Pavkov , Jorge Cortes , Anand Jillella , Amany Keruakous , Carolina Hana , Vamsi Kota

Introduction: For patients with high-risk acute myeloid leukemia (AML), defined by certain cytogenetic (CG) and molecular genetic features, hematopoietic stem cell transplantation (HSCT) remains the only curative therapy. The logistics of proceeding to transplant might necessitate consolidation chemotherapy involving high dose cytarabine (HiDAC). 

Review Article Open Access

Bispecific Antibodies and CAR-T cell Therapy in Multiple Myeloma

Margaret Locke , Amanda Lee , Maria J Nieto

Triple class exposed patients with multiple myeloma (MM) represent an unmet need with outcomes remaining poor with those with relapsed/refractory multiple myeloma (RRMM) having a mere 29.8% overall response rate and 12.4-month median overall survival. We explore emerging strategies focusing on bispecific antibodies and CAR-T cell therapies for treatment of refractory myeloma.

Editorial Open Access

Hematology and Blood Transfusion: An Indispensable Pillar of Medical Laboratory Science

Aloy-Amadi Oluchi Chinwe

Hematology and Blood Transfusion constitute one of the most distinctive and indispensable units within Medical Laboratory Science, underpinning a wide spectrum of clinical decision-making and lifesaving interventions. Discipline occupies a unique position in healthcare delivery by directly linking laboratory diagnostics with patient prognosis, therapeutic monitoring, and emergency management. Without robust hematology and transfusion services, modern clinical practice would be fundamentally compromised.

Commentary Open Access

Could Microplastics or Nanoplastics Be Driving the Lymphoma Epidemic?

Naveen Kumar

Microplastics are everywhere. Studies detect concentrations up to 1000 particles/L in seawater and up to 10 particles/cm³ in the atmosphere. Humans can be exposed to more than 48,000 microplastic particles/day through inhalation alone. These tiny fragments-smaller than 5 mm–are now in human blood, lungs, placentas, and breast milk.Our recent review termed microplastics the "hidden poison"–a phrase reflecting a troubling reality we create daily yet fail to see. 

Review Article Open Access

Edible Plants as Promising Candidates for Various Hematological Disorders: A Comprehensive Review

Acharya Balkrishna , Shreya Joshi , Rama Shankar , Uday Bhan Prajapati , Rashmi Atul Joshi

The ancient medicinal system of Ayurveda highlights the role of diet in remaining healthy and disease-free. Plants form the essential diet in Indian households, and much emphasis is laid on eating proper food at the right time interval. In recent research conducted it was found that many of the plant species widely used as vegetables in Indian cuisines are also used medicinally for the treatment of various diseases.

Commentary Open Access

Identifying Predictive Biomarkers for Immunotherapy: The Need for Minimally Invasive, Inexpensive, Broadly Applicable across Cancer Type, Pharmacodynamic Biomarkers

Simone Anfossi

Cancer immunotherapy has gained significant interest and widespread clinical application over the past few decades. The development of immune checkpoint inhibitor (ICI) antibodies that block inhibitory pathways (e.g., CTLA-4, PD-1/PD-L1) has introduced a groundbreaking new approach to cancer treatment, shifting the focus from targeting tumor cells to modulating the patient's immune response. 

Review Article Open Access

Optimal Donor Selection for Allogeneic Stem Cell Transplantation in the Era of Post-transplant Cyclophosphamide: A Scoping Review 

Matteo Bisio , Lorenzo Celona , Chiara Dellacasa , Carolina Secreto , Davide Stella , Camilla Gariazzo , Ernesta Audisio , Marco Cerrano , Roberto Freilone , Alessandro Busca

Allogeneic hematopoietic stem cell transplantation (HSCT) remains a primary curative treatment for numerous hematologic disorders. Historically, the success of HSCT relied on HLA matching to mitigate Graft-versus-Host Disease (GVHD); however, since fewer than 30% of patients have a matched family member, the field has undergone a significant paradigm shift.

Commentary Open Access

Commentary on 'Idiopathic Hyper-Eosinophilic Syndrome–A Case Based Update'

Vinodhini M

Idiopathic hypereosinophilic syndrome encompasses a less common haematologic entity which is diagnosed after exclusion of clonal, reactive, familial, and secondary causes of eosinophilia. Its diverse clinical presentation involving any organ or system is well known and may be life threatening if untreated.