Archives of Proteomics and Bioinformatics

Commentary Open Access

Commentary on “Integrative Transcriptomics, Proteomics, and Metabolomics Data Analysis Exploring the Injury Mechanism of Ricin on Human Lung Epithelial Cells”

Jing-Lin Wang

Ricin toxin (RT) is classified as a potential bio-threat agent in assassinations and terrorism due to its extreme toxicity. Due to aerosol RT exposure is the most lethal route, it is urgent to study its injury mechanism. 

Arch Proteom and Bioinform, 2023, Volume 3, Issue 1, p1-2 | DOI: 10.33696/Proteomics.3.011

Research Article Open Access

In silico Analysis for the Repurposing of Broad-spectrum Antiviral Drugs against Multiple Targets from SARS-CoV-2: A Molecular Docking and ADMET Approach

Arpana Parihar , Tabassum Zafar , Rekha Khandia , Dipesh Singh Parihar , Rupali Dhote , Yogesh Mishra , Raju Khan

SARS-CoV-2 belongs to the genus Beta of the Coronaviridae family of enveloped single-stranded, positive-sense ribonucleic acid (RNA) with a genome length of 30,000bp. The virion is composed of various non-structural (RNA dependent RNA polymerase also known as RdRp) and structural proteins such as Spike (S), Nucleocapsid (N), Matrix (M), and Envelope (E) proteins.

Arch Proteom and Bioinform, 2023, Volume 3, Issue 1, p3-14 | DOI: 10.33696/Proteomics.3.012

Commentary Open Access

Antibiotics, Efflux, and pH

Tatiana Hillman

Bacterial metabolism affects the effectiveness of antibiotics. Bacterial metabolism is linked to the ability of an antibiotic to be bactericidal or bacteriostatic because a bacterium can metabolize carbohydrates that affect its pH and its ability to use the proton motive force (PMF). When the pH is low, there is more availability of protons that can help to power the proton motive force needed for the efflux of antibiotics.

Arch Proteom and Bioinform, 2023, Volume 3, Issue 1, p15-18 | DOI: 10.33696/Proteomics.3.013