Archives of Proteomics and Bioinformatics
Commentary on “Integrative Transcriptomics, Proteomics, and Metabolomics Data Analysis Exploring the Injury Mechanism of Ricin on Human Lung Epithelial Cells”
Ricin toxin (RT) is classified as a potential bio-threat agent in assassinations and terrorism due to its extreme toxicity. Due to aerosol RT exposure is the most lethal route, it is urgent to study its injury mechanism.Arch Proteom and Bioinform, 2023, Volume 3, Issue 1, p1-2 | DOI: 10.33696/Proteomics.3.011
In silico Analysis for the Repurposing of Broad-spectrum Antiviral Drugs against Multiple Targets from SARS-CoV-2: A Molecular Docking and ADMET Approach
SARS-CoV-2 belongs to the genus Beta of the Coronaviridae family of enveloped single-stranded, positive-sense ribonucleic acid (RNA) with a genome length of 30,000bp. The virion is composed of various non-structural (RNA dependent RNA polymerase also known as RdRp) and structural proteins such as Spike (S), Nucleocapsid (N), Matrix (M), and Envelope (E) proteins.Arch Proteom and Bioinform, 2023, Volume 3, Issue 1, p3-14 | DOI: 10.33696/Proteomics.3.012
Antibiotics, Efflux, and pH
Bacterial metabolism affects the effectiveness of antibiotics. Bacterial metabolism is linked to the ability of an antibiotic to be bactericidal or bacteriostatic because a bacterium can metabolize carbohydrates that affect its pH and its ability to use the proton motive force (PMF). When the pH is low, there is more availability of protons that can help to power the proton motive force needed for the efflux of antibiotics.Arch Proteom and Bioinform, 2023, Volume 3, Issue 1, p15-18 | DOI: 10.33696/Proteomics.3.013
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