Commentary Open Access
Volume 4 | Issue 3 | DOI: https://doi.org/10.33696/Signaling.4.099

Activation of the 5-hydroxytryptamine Degradation System in Cells and Organ Injury

  • 1Department of Physiology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China
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Corresponding Author

Jihua Fu, jihua_fu@cpu.edu.cn

Received Date: June 29, 2023

Accepted Date: July 31, 2023


This paper summarizes the research results of Fu et al. on the pathological mechanism of organ injury. A hypothesis was proposed that "organ injury is a consequence of the activation of the 5-hydroxytryptamine degradation system (5DS) axis in cells". The basic composition of the 5DS axis in cells and the principle of its activation leading to cell lesions were determined. The possibility of treating various organ injury diseases in clinical practice by inhibiting the 5DS axis is discussed.


Apoptosis, Cell lesion, Inflammatory cytokines, MAPK pathway cell signaling, Mitochondrial damage, Reactive oxygen species

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