This paper summarizes the research results of Fu et al. on the pathological mechanism of organ injury. A hypothesis was proposed that "organ injury is a consequence of the activation of the 5-hydroxytryptamine degradation system (5DS) axis in cells". The basic composition of the 5DS axis in cells and the principle of its activation leading to cell lesions were determined. The possibility of treating various organ injury diseases in clinical practice by inhibiting the 5DS axis is discussed.

Apoptosis, Cell lesion, Inflammatory cytokines, MAPK pathway cell signaling, Mitochondrial damage, Reactive oxygen species