Loading
Journal of Cellular Immunology
ISSN: 2689-2812
Volume 6, Issue 4, p148-195
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
T lymphocytes in Aging: CD38 as a Novel Contributor between Inflammaging and Immunosenescence
CD38 is a transmembrane protein expressed in immune and non-immune cells involved in nicotinamide adenine dinucleotide (NAD+) consumption, cyclic Adenosine Diphosphate Ribose (cADPR) generation, and calcium mobilization by its enzymatic activity. It also promotes an activated and pro-inflammatory phenotype in immune cells. Senescence is a cellular state of cell growth arrest accompanied by senescent-associated secretory phenotype (SASP) products.
J Cell Immunol, 2024, Volume 6, Issue 4, p148-162 | DOI: 10.33696/immunology.6.201Cytoreductive Nephrectomy Following Immunotherapy: Evolution, Pearls, and Pitfalls of Treatment
Renal Cell Carcinoma (RCC) is among the most frequently diagnosed malignancies in both genders with over 81,000 estimated cases in 2024. Despite increasing incidence of renal cell carcinomas <4 cm, up to 1/3 of patients diagnosed with RCC exhibit metastatic disease (mRCC) at time of diagnosis. Cytoreductive nephrectomy (CN), a procedure which encompasses the surgical removal of the primary tumor in patients with metastatic disease
J Cell Immunol, 2024, Volume 6, Issue 4, p163-170 | DOI: 10.33696/immunology.6.202Chemokines and Their Receptors in Hepatitis B Virus Infection: A Comprehensive Review
Chemokines, a group of small cytokines, play a central role in the pathogenesis of viral hepatitis by regulating the migration, proliferation, and activation of lymphocytes. These chemotactic factors of immune cells are directly involved in various cellular biological activities, including cell adhesion, angiogenesis, and diffusion. The aberrant expression of lymphocyte chemokines and their receptors is closely related to the biological behavior of host immune cells as well as the specific and non-specific immune responses to viral infections and may influence the prognosis of viral diseases.
J Cell Immunol, 2024, Volume 6, Issue 4, p171-181 | DOI: 10.33696/immunology.6.203Clinical Case Report of CAR-T Therapy of Patient with Refractory Burkitt's Lymphoma
Approximately 20% of adult patients with Burkitt's lymphoma (BL) have relapsed/refractory disease, which is characterized by poor overall survival (OS) and virtually no therapeutic options after failure of two lines of chemotherapy, due in part to the peculiarities of tumor cell biology. Improved treatment strategies are an unmet need for these patients. There have been individual attempts to use chimeric antigen receptor (CAR)-T therapy in this patient population using anti-CD19, CD20, and CD22 cells.
J Cell Immunol, 2024, Volume 6, Issue 4, p182-187 | DOI: 10.33696/immunology.6.204Upregulated Gene Expression of Histone Deacetylases (HDAC) 1, 2, and 11 in Peripheral Blood Mononuclear Cells of Rheumatoid Arthritis Patients
The histone deacetylase (HDAC) family consists of epigenetic modifiers that demonstrate anti-inflammatory activities, and hence they might have a substantial role in auto-inflammatory disorders including rheumatoid arthritis (RA). Therefore, the aim of this study is to investigate the expression of HDAC1, HDAC2, and HDAC11 genes in peripheral blood mononuclear cells (PBMCs) of RA cases compared to healthy controls.
J Cell Immunol, 2024, Volume 6, Issue 4, p188-195 | DOI: 10.33696/immunology.6.205Is Citrate A Critical Signal in Immunity and Inflammation?
When immune cells are activated, they undergo metabolic change in order to have sufficient energy to function effectively. The Krebs cycle is one of the most important pathways involved in this response and citrate, a critical component of this pathway, regulates carbohydrate and lipid metabolism.
The Link of Nutrient Fluxes to Hepatic Insulin Resistance at Gene Expression
Insulin resistance has been studied extensively at systemic, organ, tissue and cellular and molecular levels. Overnutrition plays an essential role in the development of chronic metabolic diseases such as obesity and type 2 diabetes. For subjects without genetic defects, the development of insulin resistance and type 2 diabetes is a graduate process. How the transition from an insulinsensitive state to an insulin-resistant state occurs, and what the roles of nutrients are in the process have not been fully understood. Here, we try to summarize the current understanding of insulin-regulate gene expression in the liver, and describe a phenomenon of hepatic insulin resistance at gene expression (HIRAGE), which may be linked to overnutrition.
No Studies in Stroke Regarding Brain fMRI Activity and Pelvic Floor Muscle Training/Activation - Only Studies in Non-stroke Population: A Review of Neuroimaging Studies
Neurogenic lower urinary tract dysfunction (NLUTD) is highly prevalent in poststroke patients, leading to major impact on the quality of life (QoL) and healthcare resources. Pelvic floor muscle training (PFMT) has, over the past two decades, been recommended as first-line treatment for neurologically healthy patients with lower urinary tract symptoms (LUTS).
Dendorbium Nobile Lindl. Alkaloids Suppress NF-κB and NLRP3 Signaling Pathways to Attenuate Lipopolysaccharide-induced Neuroinflammation
The important immune cells in the brain are called microglia acting as the central junction between neuroinflammation and neurodegenerative diseases. In patients of cognitive disorders and Alzheimer’s disease (AD) animal models, amoebic morphology and inflammatory pathways are activated to release numerous cells in the inflammatory factors by active microglia.
TNFAIP8: Inflammation, Immunity and Human Diseases
Inflammation can be caused by various environmental factors, including microbial infection and toxic chemical exposure. In response to inflammation, immune cells like macrophages, B and T lymphocytes, fibroblasts, endothelial cells, and various stromal cells secrete soluble polypeptide cytokine Tumor Necrosis Factor Alpha (TNF?)
Cellular Response to Stress: At the Crossroads between Immunosenescence and Cancer
Aging is a complicated process not yet fully understood. Driven by a variety of stressors such as infectious agents, radiation, intracellular stress, and stressing metabolic conditions, molecular damage occurs over time. Among many consequences, age-related unchecked molecular damage leads to immunosenescence, a hallmark of aging.
ProLung™-budesonide Inhibits SARS-CoV-2 Replication and Reduces Lung Inflammation
Inhaled budesonide benefits patients with COVID-19. ProLung™-budesonide enables the sustained, low dose administration of budesonide within a delivery vehicle similar to lung surfactant.
S1P Generation by Sphingosine Kinase-2 in Recruited Macrophages Resolves Lung Inflammation by Blocking STING Signaling in Alveolar Macrophages
Acute respiratory distress syndrome (ARDS) is the major cause of mortality among hospitalized acute lung injury (ALI) patients. Lung macrophages play an important role in maintaining the tissue-fluid homeostasis following injury. We recently showed that circulating monocytes recruited into the alveolar space suppressed the stimulator of type 1 interferon genes (STING) signaling in alveolar macrophages through sphingosine-1-phosphate (S1P).
Study on Imaging Findings, Pathology and Treatment of Cerebellar Infarction
To explore the pathological mechanism and clinical treatment of cerebellar infarction through the clinical imaging changes of cerebellar infarction.
Arid5a Inroads to Immunity, Inflammation, and Cancer
The immune system is essential to host defense because it senses attacking pathogens and elicits protective immune responses. Although immune responses can protect against pathogens, uncontrolled immune responses cause tissue damage and other pathological consequences through their inflammatory mediators.
Physiotherapy Exercise Program for Managing Adhesive Capsulitis in Patients with and without Diabetes: A Pilot Randomized Trial
Adhesive capsulitis (AC), also known as ‘frozen shoulder’, is characterized by the development of dense adhesions and capsular thickening leading to a progressive and painful restriction of shoulder range of motion (ROM) and functional disability [1]. The onset is gradual, usually occurs between the ages of 40 and 60 years and is more common in females and diabetics.
Elucidating the Role of Chemokines in Infectious Diseases and Gastric Cancer
Although the prevalence of gastric cancer is decreasing in many developed nations, it is the fourth most prevalent cancer and the second leading cause of cancer-related deaths globally. Around 8 percent of recently diagnosed malignant tumors are stomach cancer, more than 7,00,000 individuals die from gastric cancer yearly. Despite extensive research into new diagnostic and therapeutic methods, the prognosis for individuals with advanced stomach cancer remains dismal, and survival rates have hardly improved. In recent years, many latest innovations have improved our understanding of the molecular mechanisms and modifications that contribute to gastric cancer’s beginning and progression, including several genetic and molecular modifications and mutations.
Managing Acute Urinary Dysfunction for Neurologic Injury Patients
Damage to the nervous system can have direct and indirect impact on the lower urinary tract. Broadly speaking, damage can be grouped into three categories: problems with bladder storage, stress incontinence, and problems with bladder emptying [1].
Quantifying Neural Stem Cell-Derived Extracellular Vesicle Uptake Using Imaging Flow Cytometry
Nanomedicine, which includes nanoparticles and other nanomaterials for diagnosis and therapeutic delivery to treat numerous diseases, is making advances.
Friend or Foe? Opposing Functions of O-GlcNAc in Regulating Inflammation
Effector CD4+ T cells (i.e. Th1, Th2, Th17) are essential in the adaptive immune system’s specific elimination of different classes of pathogens, such as viruses, bacteria, and parasites, while regulatory T cells shut these inflammatory responses off once a pathogen has been cleared [1]. Interestingly, effector T cells preferentially utilize
Is Cellular Senescence of Dopaminergic Neurons the Cause of Local Inflammation in the Midbrain Observed in Parkinson’s Disease?
Current research investigating the pathomechanisms of neurodegenerative disorders of the central nervous system (CNS), such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), or Parkinson’s disease (PD), led to the understanding that these diseases have to be seen in the context of immune responses [1]. In other words,
Function of Mitogen-Activated Protein Kinases in Hepatic Inflammation
The western diet and overuse of anti-inflammatory medication have caused a great deal of stress on the liver. Obesity and the associated inflammatory state in insulin-responsive tissues result in the release of pro-inflammatory cytokine that activates the stress-responsive MAPKs, p38 MAPK, and JNK. These MAPKs have figured prominently as critical effectors in physiological and pathophysiological hepatic inflammation.
Lessons from My Grandmother’s Garden: Intergenerational Learning and Managing Type 2 Diabetes
Researchers suggest that grandmothers are often the invisible support helping to maintain the health and well-being of the family and community. Studies have explored the important role that grandmothers play in the well-being of families over time.
ZBP1, a dsRNA Sensor for Cell Death and Inflammation
ZBP1 has aroused a wide interest since it was identified as the first cytosolic dsDNA sensor ahead of the finding of cGAS in 2013. However, the investigations on ZBP1 declined when researchers found the binding of ZBP1 with dsDNA is not absolutely required for the activation of innate response.
Chronic IL-1 Exposed AR+ PCa Cell Lines Show Conserved Loss of IL-1 Sensitivity and Evolve Both Conserved and Unique Differential Gene Expression Profiles
Inflammation drives prostate cancer (PCa) progression. While inflammation is a cancer hallmark, the underlying mechanisms mediating inflammation-induced PCa are still under investigation. Interleukin-1 (IL-1) is an inflammatory cytokine that promotes cancer progression, including PCa metastasis and castration resistance. We previously found that acute IL-1 exposure represses PCa androgen receptor (AR) expression concomitant with the upregulation of pro-survival proteins, causing de novo accumulation of castration-resistant PCa cells.
Scientific Archives is a global publisher initiated with the mission of ensuring equal opportunity for accessing science to research community all over the world. Spreading research findings with great relevance to all channels without any barrier is our goal. We want to overcome the challenges of Open Access with ensured quality and transparency.