Loading
Journal of Experimental Neurology
ISSN: 2692-2819
Volume 4, Issue 1, p1-42
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
Muscle and Its Neuromuscular Synapse – Players in the Pathogenesis of Motor Neuron Disease
Motor Neuron Disease (MND) of which Amyotrophic lateral sclerosis (ALS) is the most common form, is a devastating disorder where approximately 80% of patients die within 3-5 years of diagnosis. The highly variable clinical presentation, course, and prognosis between individuals suggests that a variety of factors underlie the pathogenesis of the disease.
J Exp Neurol, 2023, Volume 4, Issue 1, p1-5 | DOI: 10.33696/Neurol.4.067Current Spinal Cord Injury Animal Models are Too Simplistic for Clinical Translation
Spinal cord injury (SCI) is a devastating disease that has a global impact on individuals and society. The number of SCI cases in 2016 was 27 million worldwide, which was predominantly due to falls and road traffic collisions. Alarmingly, the number of new SCI cases in most countries has risen over the last few decades.
J Exp Neurol, 2023, Volume 4, Issue 1, p6-10 | DOI: 10.33696/Neurol.4.068Cisterna Magna Injection Mouse Model of Subarachnoid Hemorrhage (SAH): A Systematic Literature Review of Preclinical SAH Research
This review article describes the characteristics of published literature using the cisterna magna blood injection mouse model of subarachnoid hemorrhage (SAH) with the aim to define particular standards and identify moderators of mortality rate, SAH grade, and large artery vasospasm.
J Exp Neurol, 2023, Volume 4, Issue 1, p11-20 | DOI: 10.33696/Neurol.4.069The Ventral Tegmental Area (VTA), the Nucleus Accumbens (NAc), the Caudate Nucleus (CN) and the Prefrontal Cortex (PFC) role in the Response to Acute and Chronic Methylphenidate
Methylphenidate (MPD) is psychostimulant, similar to cocaine and amphetamine, that is commonly used to treat attention deficit hyperactivity disorder and is increasingly being abused by healthy subjects for its psychoactive effects such as memory retention cognitive enhancement for young, adult and the elderly and recreation. MPD’s action on the brain reward/motive circuit is still under investigation
J Exp Neurol, 2023, Volume 4, Issue 1, p21-36 | DOI: 10.33696/Neurol.4.070Benefits of Routine Inpatient EEG in Practice: Experience from a Level 4 University Hospital
Routine inpatient EEGs have been part of epilepsy practices for years. We aim to improve current routine EEG practices by studying their role at a large university hospital. Methods: Inpatient routine EEGs from January-July 2021 were included and patients <5 yrs., EEGs repeated on the same patient were excluded. Indications, floor status, abnormality, day of study, neurology consultation, results, treatment changes, discharge status, and prior AED use were analyzed using SAS 9.4.
J Exp Neurol, 2023, Volume 4, Issue 1, p37-42 | DOI: 10.33696/Neurol.4.071VA-Radiation Oncology Quality Surveillance Program: Enhancing Quality Measure Data Capture, Measuring Quality Benchmarks and Ensuring Long Term Sustainability of Quality Improvements in Community Care
High quality cancer care improves patient survival and quality of life. Radiation plays an important role in cancer management, given that over 50% of all cancer patients receive radiation therapy as either a primary treatment or for palliation. Ensuring quality of radiotherapy specifically, is therefore important to achieving optimal patient outcomes.
Psychosocial Aspects of Drug Prescription: Recognizing These Phenomena to Improve the Quality of Clinical Practice
The medical prescription corresponds to a complex act, which requires knowledge, professional experience, specific skills, a great sense of responsibility and an ethical attitude.
Dexamethasone: The First Drug to be Shown to Decrease Mortality in Critically Ill Patients with COVID-19
The precise role of corticosteroids for treatment of coronavirus disease 2019 (COVID-19) is unclear due to lack of randomized trials.
Pharmacogenetic Variants in the DPYD and TYMS Genes are Clinically Significant Predictors of Fluoropyrimidine Toxicity: Are We Ready for Use in our Clinical Practice
Fluoropyrimidines have been extensively used for almost 6 decades to treat a variety of solid cancers, especially colon, gastric, anal, rectal, head & neck and breast. However, 31–34% of patients encountered grade 3–4 adverse events (AEs) with 0.5% mortality oftennecessitating dose reduction or discontinuation.
Galectin 3 and Glial Cells of the CNS: A Fruitful Crosstalk with Remyelinating Potential
Galectin-3 (Gal-3), the only chimera-like galectin, has three structural domains: (a) the NH2 terminal domain containing serine phosphorylation, important for nuclear localization, secretion and oligomerization; (b) a sequence susceptible to metalloprotease (MMP) cleavage; and (c) a C-terminal domain containing the carbohydrate recognition domain (CRD) and an anti-death motif.
Rapid Inactivation of SARS-CoV-2 by Coupling Tungsten Trioxide (WO3) Photocatalyst with Copper Nanoclusters
At the end of 2019, a novel severe respiratory disease (coronavirus disease 2019, COVID-19) spread to Wuhan, China, it became pandemic in few months, with more than 41 million people infected worldwide as of October 2020. COVID-19 is caused by a novel virus called severe acute respiratory syndrome (SARS) CoV-2 to distinguish it from SARS-CoV that emerged in Guangdong province in China in 2003 and caused the severe clinical condition known as SARS. Like SARS-CoV, SARS- CoV-2 causes a severe inter
Neuromotor Impairment, Hearing Loss and Blindness in a Preclinical Mouse Model of Charcot Marie-Tooth Disorder
In the peripheral nervous system (PNS), Schwann cells (SCs) are responsible for myelin production, which contributes to axonal protection and allows for efficient action potential transmission. Unfortunately, acquired and hereditary demyelinating diseases of the PNS are numerous and affect an increasing number of people.
Commentary on – ISPAD Clinical Practice Consensus Guidelines: Fasting during Ramadan by Young People with Diabetes
This is a commentary on the recent work by our group on fasting during Ramadan by young people with diabetes which was published as ISPAD Clinical Practice Consensus Guidelines. In this commentary, themes of selected studies published following the guidelines release are highlighted.
Resveratrol Treatment Reduces Neuromotor Impairment and Hearing Loss in a Mouse Model of Diabetic Neuropathy and Nerve Injury
In the peripheral nervous system (PNS), Schwann cells (SCs) are responsible for myelin production, which contributes to axonal protection and allows for efficient action potential transmission. Unfortunately, acquired and hereditary demyelinating diseases of the PNS are numerous and affect an increasing number of people.
Cervical Cancer Prevalence in sub-Saharan Africa and HPV Vaccination Policy: A Public Health Grand Challenge?
“Women are not dying because of diseases we cannot treat. They are dying because societies have yet to make the decision that their lives are worth saving.”
The Silencing of Casein Kinase I Attenuated Neuromuscular Impairment in a Preclinical Mouse Model of Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis (ALS) is a fatal progressive neurodegenerative disease, which results in the destruction of upper and/or lower motor neurons in the brain and spinal cord. It usually affects people between 40 and 60-year-old and the average survival from onset to death is 3–4 years [1].
Friend or Foe? Opposing Functions of O-GlcNAc in Regulating Inflammation
Effector CD4+ T cells (i.e. Th1, Th2, Th17) are essential in the adaptive immune system’s specific elimination of different classes of pathogens, such as viruses, bacteria, and parasites, while regulatory T cells shut these inflammatory responses off once a pathogen has been cleared [1]. Interestingly, effector T cells preferentially utilize
Use of Humanized Mouse Models for Studying HIV-1 Infection, Pathogenesis and Persistence
Different humanized mouse models have been introduced to enable HIV-1 research in vivo, which has been made possible by the development of immunodeficient mouse strains.
Prediction of Severity and Mortality in Acquired Thrombotic Thrombocytopenic Purpura (aTTP). Utility of Clinical-biological Scores
Acquired thrombotic thrombocytopenic purpura (aTTP) is a life-threatening thrombotic microangiopathy (TMA). It has an average annual prevalence of approximately 10 cases/million people and an annual incidence between 1.5 and 6.0 cases per million according to studies conducted in France, the United States, the United Kingdom, and Spain. The first episode of aTTP occurs mostly during adulthood (~90% of all aTTP cases), but some child and adolescent forms are also detected (~10% of cases).
Primary Angiitis of the Central Nervous System (PACNS): A Commentary on a Proposed Screening Algorithm and an Update on Diagnosis and Treatment
Primary angiitis of the central nervous system (PACNS) is a rare disorder difficult to suspect in clinical practice due to its rarity, not specific/protean clinical presentation and imaging findings
Combined Antiseizure Efficacy of Cannabidiol and Clonazepam in a Conditional Mouse Model of Dravet Syndrome
Dravet syndrome (DS) is an intractable childhood epilepsy disorder affecting one in 15,000 to 20,000 births [1]. It is caused by de novo heterozygous lossof- function mutations in the SCN1A gene encoding the brain type-I voltage-gated sodium channel Nav1.1
Commentary: Experimental Mouse Models of Invasive Candidiasis Caused by Candida auris and Other Medically Important Candida Species
Disseminated candidiasis is the leading cause of lifethreatening fungal infections in humans. This is especially the case in immunocompromised individuals, and in hospitalized patients including intensive care unit patients.
A Challenging Case of Central Nervous System Involvement (CNSi) with Chronic Lymphocytic Leukemia (CLL): A Case Report
Chronic Lymphocytic Leukemia (CLL) is a mature B cell neoplasm characterized by a progressive accumulation of monoclonal B lymphocytes. It manifests primarily in the blood. Infiltration of CLL lymphocytes outside of this site is relatively rare and is defined as extra medullary CLL.
Targeting the Complex Protein Network of MYCN-amplified Anaplastic Ependymoma: A Case Report
The MYCN oncoprotein has been notoriously undruggable and is infamous for causing aggressive cancer with poor outcomes in children and adults. Following surgery, radiation, and chemotherapy, patients who develop progressive disease have few treatment options. An analysis of the dysregulated protein network caused by MYCN amplification suggested co-targeting PLK1, AURKA, CKS1, AKT, MTOR, and USP7 would be useful to take advantage of synthetic lethal vulnerabilities
Neuroinflammation and Microglial Polarity: Sirolimus Shifts Microglial Polarity to M2 phenotype in a Mouse Model of Tuberous Sclerosis Complex
Tuberous sclerosis complex (TSC) is a neurocutaneous syndrome characterized by systemic hamartomas, including skin and neural symptoms. Many patients exhibit epilepsy, intellectual disability, autism, and other behavioral and neuropsychiatric symptoms, referred to as TSCassociated neuropsychiatric disorders (TAND).
Scientific Archives is a global publisher initiated with the mission of ensuring equal opportunity for accessing science to research community all over the world. Spreading research findings with great relevance to all channels without any barrier is our goal. We want to overcome the challenges of Open Access with ensured quality and transparency.