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Journal of Experimental Neurology
ISSN: 2692-2819
Volume 3, Issue 3, p63-81
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
Neuroinflammation and Microglial Polarity: Sirolimus Shifts Microglial Polarity to M2 phenotype in a Mouse Model of Tuberous Sclerosis Complex
Tuberous sclerosis complex (TSC) is a neurocutaneous syndrome characterized by systemic hamartomas, including skin and neural symptoms. Many patients exhibit epilepsy, intellectual disability, autism, and other behavioral and neuropsychiatric symptoms, referred to as TSCassociated neuropsychiatric disorders (TAND).
J Exp Neurol, 2022, Volume 3, Issue 3, p63-70 | DOI: 10.33696/Neurol.3.064Commentary: Calcitonin Gene Related Peptide and Its Clinical Utility for the Treatment of Traumatic Brain Injury, Subarachnoid Hemorrhage and Associated Migraine
Calcitonin gene related peptide (CGRP) is a potent vasodilator and neurotransmitter that has been extensively studied in the context of migraine pathophysiology. Recently, studies have explored its role in the treatment of traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH). Although a multitude of therapies exist for migraine, there has been little study on the management of migraine following neurologic injury.
J Exp Neurol, 2022, Volume 3, Issue 3, p71-74 | DOI: 10.33696/Neurol.3.065The Jalisco Mutation: Familiar Alzheimer’s Disease in México
Before the age of 65, people with mutations in the genes for Presenilin 1 (PSEN1), Presenilin 2 (PSEN2), and the amyloid precursor protein (APP) experience familial Alzheimer’s disease (FAD). The sporadic type of Alzheimer’s disease (AD) is multifactorial and associated with the Apolipoprotein E ε4 allele (APOE ε4), which can up to 12 times increase the risk of getting the condition
J Exp Neurol, 2022, Volume 3, Issue 3, p75-77 | DOI: 10.33696/Neurol.3.066An Updated Overview of Alzheimer’s Disease
Alzheimer’s Disease (AD) is the most common form of dementia. Patients diagnosed with AD experience disordered cognition and memory, as well as changes in behaviour and personality. The vast majority of AD is diagnosed in patients aged over 65 years and classified as late onset (LOAD), with the remaining ~1% of cases termed early onset AD (EOAD).
J Exp Neurol, 2022, Volume 3, Issue 3, p78-81 | DOI: 10.33696/Neurol.3.067Mega-Dose Dietary Riboflavin in Treatment in Keratoconus, Post-Refractive Cornea Ectasia and Migraine. Has Its Time Arrived?
Recently, several studies and investigators have shown the beneficial effects of high dose dietary riboflavin (vitamin B2) in the treatment of keratoconus, post-refractive (LASIK, PRK & Radial Keratotomy) ectasia (with sunlight exposure) and patients treated with our own protocol (NIH Clinical Study – www.clinicaltrials.gov - # NCT 03095235) discovered significant relief for intractable migraine headaches and/or ophthalmic migraine (classic migraine visual symptoms without headache).
Exercise Benefits on Alzheimer’s Disease
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder [1] and the most common cause of human dementia, accounting for approximately 60%?80% of cases. It is estimated that more than 30 million AD patients, and the number likely to increase to over 100 million by 2050 because of the increase of the elderly population [2].
Comparative Effect of Levetiracetam and Carbamazepine versus Levetiracetam and Sodium Valproate on Seizure Frequency in Patients with Epilepsy
Epilepsy involves one or a group of chronic disorders in which seizures recur unprovoked and unpredicted. Epidemiological studies in the United States estimate that about 2 million people have epilepsy. About 44 cases per 100,000 people annually are diagnosed with epilepsy, which is about 1% in the United States at the age of about
Epilepsy in Neurodegenerative Disease: A Commentary
Case Summary - We published a case report of a 22-year-old woman who presented to our university hospital with encephalopathy and left hemiparesis of a few weeks duration.
To Stick or Not to Stick? Scalp and Intracranial EEG Evaluation Both Help Achieve Good Surgical and Neuropsychiatric Outcomes in Epilepsy Surgery up to 20 Years Post-Surgery
Epilepsy has a worldwide prevalence of about 50 million [1]. Seizure medications provide adequate control in two thirds of these patients but about a third are refractory to multiple medications and need surgery or other treatments [2].
Intracranial Pressure Monitoring in Aneurysmal Subarachnoid Hemorrhage -Current Practices and Challenges
The annual incidence of aneurysmal subarachnoid hemorrhage (SAH) in the United States is 6-16 cases per 100,000 population, with approximately 30,000 cases occurring each year.
Microptofluidic Technology for Biodiagnostics of Traumatic Brain Injury: A Commentary
Traumatic brain injury (TBI) is a leading cause of death and neurological disability worldwide with millions of people sustaining and living with its long-term effects []. TBI is often categorized as mild, moderate and severe with primary injuries separated as either focal or diffuse, with the latter including contusions, intracranial hematomas and brain herniation.
Effect of Exosomes on Alzheimer’s Disease
AD is a neurodegenerative disease characterized by progressive cognitive impairment, behavioral changes, memory loss and executive dysfunction, all of which present serious threats to the health of older people.
Differential Fecal Microbiome Dysbiosis after Equivalent Traumatic Brain Injury in Aged Versus Young Adult Mice
Traumatic brain injury (TBI) has a bimodal age distribution with peak incidence at age 24 and age 65 with worse outcomes developing in aged populations
Virtual Reality Zoo Therapy: An Interactive Relaxing System for Alzheimer’s Disease
The number of people with Alzheimer’s disease (AD) is on the rise, yet there is no effective pharmacological treatment that can slow or reverse the disease’s progress
Much is Known about Caregiver Burden in Dementia - What is Next? The Role of Comorb idities and Future Perspectives
Care for patients with chronic debilitating neurological diseases is often demanding and can result in a variety of negative consequences including mental and physical morbidity.
Environmental Enrichment and Its Benefits for Migraine: Dendritic Cell Extracellular Vesicles as an Effective Mimetic
Migraine is a common neurological disorder characterized by episodic intense and painful headaches that last between 4 and 72 hours. Typically, the headache is unilateral and pulsating, aggravated by physical activity, and often accompanied with nausea, dizziness, photophobia, hyperosmia, or phonophobia.
Commentary: Calcitonin Gene Related Peptide and Its Clinical Utility for the Treatment of Traumatic Brain Injury, Subarachnoid Hemorrhage and Associated Migraine
Calcitonin gene related peptide (CGRP) is a potent vasodilator and neurotransmitter that has been extensively studied in the context of migraine pathophysiology. Recently, studies have explored its role in the treatment of traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH). Although a multitude of therapies exist for migraine, there has been little study on the management of migraine following neurologic injury.
Glucose Metabolism is a Better Marker for Predicting Clinical Alzheimer’s Disease than Amyloid or Tau
Alzheimer’s disease (AD) research has long been dominated with communications regarding the amyloid hypothesis and targeting amyloid clearance through pharmacological therapies from the brain [1].
Inulin Supplementation Mitigates Gut Dysbiosis and Brain Impairment Induced by Mild Traumatic Brain Injury during Chronic Phase
Approximately 1.6-3.8 million people sustain a mild traumatic brain injury (mTBI) in the US annually. This amounts to the hospitalization of 100-300 per 100,000 young adults. The Centers for Disease Control and Prevention reports that around 5.3 million people live with a permanent disability after mTBI, and there are currently no known restorative therapies.
Human Gray and White Matter Metabolomics to Differentiate APOE and Stage Dependent Changes in Alzheimer’s Disease
Alzheimer’s disease (AD) is a leading cause of death and morbidity in the United States [1]. The hallmarks of AD are β-amyloid (Aβ) and tau. However, studies have indicated that metabolic dysfunction may play a more pivotal role in the progression of AD [2]. Glucose hypometabolism and mitochondrial dysfunction are well-known features of AD [2].
An Updated Overview of Alzheimer’s Disease
Alzheimer’s Disease (AD) is the most common form of dementia. Patients diagnosed with AD experience disordered cognition and memory, as well as changes in behaviour and personality. The vast majority of AD is diagnosed in patients aged over 65 years and classified as late onset (LOAD), with the remaining ~1% of cases termed early onset AD (EOAD).
Neuroinflammation and Microglial Polarity: Sirolimus Shifts Microglial Polarity to M2 phenotype in a Mouse Model of Tuberous Sclerosis Complex
Tuberous sclerosis complex (TSC) is a neurocutaneous syndrome characterized by systemic hamartomas, including skin and neural symptoms. Many patients exhibit epilepsy, intellectual disability, autism, and other behavioral and neuropsychiatric symptoms, referred to as TSCassociated neuropsychiatric disorders (TAND).
The Jalisco Mutation: Familiar Alzheimer’s Disease in México
Before the age of 65, people with mutations in the genes for Presenilin 1 (PSEN1), Presenilin 2 (PSEN2), and the amyloid precursor protein (APP) experience familial Alzheimer’s disease (FAD). The sporadic type of Alzheimer’s disease (AD) is multifactorial and associated with the Apolipoprotein E ε4 allele (APOE ε4), which can up to 12 times increase the risk of getting the condition
Cisterna Magna Injection Mouse Model of Subarachnoid Hemorrhage (SAH): A Systematic Literature Review of Preclinical SAH Research
This review article describes the characteristics of published literature using the cisterna magna blood injection mouse model of subarachnoid hemorrhage (SAH) with the aim to define particular standards and identify moderators of mortality rate, SAH grade, and large artery vasospasm.
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