Journal of Nanotechnology and Nanomaterials

2025

Volume 6, Issue 1, p1-94

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Editorial Open Access

Functionalized Carbon Nano-onions for Polymer Composites

Ahmad Adlie Shamsuri

Functionalized CNOs can be tailored through chemical modifications to enhance their compatibility with various polymer matrices, a practice that has seen increasing utilization across diverse fields. This editorial article examines the role of these functionalized nanoparticles in revolutionizing polymer composites, specifying briefly the techniques for their functionalization, the general types of polymer matrices used, their effects on composite properties, and their broadening range of applications.

J Nanotechnol Nanomaterials, 2025, Volume 6, Issue 1, p1-3 | DOI: 10.33696/Nanotechnol.6.057

Commentary Open Access

Cardiac Stents from Research to Clinical Applications

Shabnam Hashemzadeh, Saber Hashemzadeh, Fateme Bina

Early diagnosis and treatment of atherosclerosis are of vital importance in cardiology. Because of high risk and complexity of open-heart surgery, nowadays balloon angioplasty and stent implantation are common techniques to extend arterial vessels narrowed by atherosclerosis. Serious drawbacks of previous stents, such as complications induced by delayed healing and local hypersensitivity reactions and so re-narrowing and vascular reocclusion, have led to the development of stent designs, stent delivery systems, ultrasonic guidance of stent situation, and high-pressure dilatation post-stenting modifications [2-5].

J Nanotechnol Nanomaterials, 2025, Volume 6, Issue 1, p4-11 | DOI: 10.33696/Nanotechnol.6.058

Research Article Open Access

Recent Advances in Different Nanoprecipitation Methods for Efficient Drug Loading and Controlled Release

A. W. Zaibudeen

Nanoprecipitation has emerged as a versatile and efficient technique for formulating nanoparticles, providing significant advantages in drug delivery applications. Nanomaterials, particularly polymer nanoparticles (PNPs), play a crucial role in encapsulating and controlling the release of drug molecules, serving as an alternative to traditional drug delivery methods. Various types and morphologies of PNPs have been synthesized using different nanoprecipitation methods that are being used as drug carriers, demonstrating superior performance in targeted drug delivery with controlled release compared to conventional methods.

J Nanotechnol Nanomaterials, 2025, Volume 6, Issue 1, p12-25 | DOI: 10.33696/Nanotechnol.6.059

Commentary Open Access

Comment on “Cholesterol Induced Asymmetry in DOPC Bilayers Probed by AFM Force Spectroscopy”

Dhruva Bhat, Appala Venkata Ramana Murthy

In the recent article, Adhyapak et al., used Atomic Force Microscopy (AFM) and Force Spectroscopy to investigate the influence of cholesterol on the phase state behaviour of fluid phase DOPC membranes and found that the excess cholesterol conditions (above 20%) can induce an asymmetry in the lipid bilayer leading to changes both topography and more significantly in the nanomechanical properties of the lipid bilayer.

J Nanotechnol Nanomaterials, 2025, Volume 6, Issue 1, p26-27 | DOI: 10.33696/Nanotechnol.6.060

Review Article Open Access

Nanoscale Diagnosis and Therapy: Nanotheranostics as an Advance in Nanotechnology

Bianca Pizzorno Backx

The term "nanotechnology," introduced in 1986, refers to the emergence of a novel technology poised to transform existing protocols at the nanoscale. For many years, publications regarding nanotechnology have generated significant expectations related to discoveries and solutions. In 1990, with the inception of green chemistry, the scientific community began to reassess its approach, inspired by adaptations of protocols established by various eco-friendly institutions.

J Nanotechnol Nanomaterials, 2025, Volume 6, Issue 1, p28-42 | DOI: 10.33696/Nanotechnol.6.061

Review Article Open Access

Cutting-Edge Nanoparticle Innovations in Biomedical Science: Synthesis, Applications, Challenges, and Future Prospects

Joicy John

Nanoparticles (NPs), identified as particles measuring between 1 and 100 nanometers, exhibit distinct physical and chemical properties that set them apart from larger materials. These attributes, which encompass a substantial surface area relative to volume and quantum phenomena, render them highly across various sectors.

J Nanotechnol Nanomaterials, 2025, Volume 6, Issue 1, p43-66 | DOI: 10.33696/Nanotechnol.6.062

Short Communication Open Access

Development of Functional Nano-, Micro-Biostructures with Generation of New Enhanced Light Pathways for Life Science Applications

Daniela Alejandra Quinteros, M. Valeria Amé, A. Guillermo Bracamonte

Life sciences involve a broad overview of fundamental research of high interest, accompanied by the development of applications based on emerging needs. The generation of non-classical light is a high-impact area of research that could lay the foundation for functional materials, particularly in applications requiring tracking and switchable (on/off) properties. In this regard, the present communication is intended to present and discuss how natural and synthetic bio-structures, along with Nanotechnology, could provide versatile platforms for developing functional and multi-functional structures accompanied by the generation of novel non-classical light pathways.

J Nanotechnol Nanomaterials, 2025, Volume 6, Issue 1, p67-75 | DOI: 10.33696/Nanotechnol.6.063

Original Research Open Access

Enhancing p-type DSSC Performance through Nio-carbon Allotrope Hybrids: A Study of Functionalized MWCNT Integration

Nidhi Prajapati, Chivukula Narayana Murthy

In this study, we systematically investigated the influence of various carbon allotropes on the photovoltaic performance of p-type dye-sensitized solar cells (DSSCs) using nickel oxide (NiO) nanotubes as the base semiconductor. The selected carbon nanostructures multi-walled carbon nanotubes (MWCNTs), reduced graphene oxide (RGO), graphene quantum dots (GQDs), and fullerenes (C₆₀) were integrated with NiO and evaluated based on their structural and electrochemical characteristics.

J Nanotechnol Nanomaterials, 2025, Volume 6, Issue 1, p76-88 | DOI: 10.33696/Nanotechnol.6.064

Perspective Open Access

Weak Interactions in Catalysis

Xinyu Guo, Ziyang Feng, Bingyuan Zeng, TingTing Xia, Yuetong Zhao, Wenliang Zhang, Zumin Wang, Kun Zhao

Traditional catalytic theory has predominantly centered on static chemical bond processes, specifically the weakening, breaking, strengthening, and formation of chemical bonds – representing relatively fixed patterns of transformation. Whereas the dynamic regulatory mechanisms of weak interactions have been relatively understudied. This paradigm shift emerges from recognizing how precisely engineered 3D spatial arrangements govern catalytic efficiency: directional hydrogen bonds, size-matched hydrophobic cavities, and π-π stacking at optimal distances collectively create confined microreactors that steer reaction pathways.

J Nanotechnol Nanomaterials, 2025, Volume 6, Issue 1, p89-94 | DOI: 10.33696/Nanotechnol.6.065

Submit Manuscript

Recommended Articles

Chimeric Antigen Receptor CAR NK Cells Emerging Immunotherapy for the Treatment of Cancer

Although NK cells are recognized as effector lymphocytes of the innate immune system, they also regulate the adaptive immune response by releasing inflammatory cytokines and developing immunological memory. Unlike other lymphocytes such as T or B cells, NK cells do not express rearrangeable, antigen-specific receptors.

pMB FLASH - Status and Perspectives of Combining Proton Minibeam with FLASH Radiotherapy

Proton minibeam radiotherapy (pMBRT) is an external beam radiotherapy method with reduced side effects by taking advantage of spatial fractionation in the normal tissue. Due to scattering, the delivered small beams widen in the tissue ensuring a homogeneous dose distribution in the tumor. In this review, the physical and biological principles regarding dose distribution and healing effects are explained. In the last decade, several preclinical studies have been conducted addressing normal tissue sparing and tumor control in-vitro and in-vivo, using human skin tissue and mouse or rat models. The major results acquired in these studies are summarized. A further newly emerging therapy method is FLASH radiotherapy, i.e. the treatment using ultra-high dose rates. The possibility of combining these methods in proton minibeam FLASH therapy (pMB FLASH) is worked out. Additionally, technical feasibility and limitations will be discussed by looking at simulations as well as preclinical studies and also pointing out new ways of delivering the desired tumor dose, such as interlacing. We will also highlight the opportunities that emerge regarding high dose radiation, hypofractionation and the combination with immunotherapy.

Emerging Role of TRPML1 Mucolipin Endolysosomal Channel in Cancer

The transient receptor potential mucolipin 1 (TRPML1) is an endolysosomal channel belonging to the TRP family. Clinically, mutations of TRPML1 have been responsible for a severe lysosomal storage disorder called mucolipidosis type IV.

Cyclic Nucleotide Signaling Pathways in Apicomplexan Parasites Provide a Valuable Source for Novel Drug Targets

Malaria is one of the most important disabling human, tropical disease caused by different Plasmodium species, which are protozoan parasites belonging to the Apicomplexa. The Apicomplexan parasites have a plastid like structure the “apicoplast” and comprise the genera Plasmodium, Toxoplasma and Cryptosporidium causing malaria, toxoplasmosis, and cryptosporidiosis.

Circulating Cell-Free RNA: A New Perspective for Endometrial Cancer

In order to implement the knowledge of cancer to monitor its evolution and setting, in the last decade, new minimally invasive and repeatable samples collection have been developed such as liquid biopsy. Cancer biomarkers originating from tumors can represent the molecular status of the tumor or its metastases which release them directly into body fluids or indirectly due to disruption of tumor/metastatic tissue. These biomarkers are detectable in liquid biopsy.

CO-Releasing Materials: Therapeutic Implications and Challenges towards Drug Discovery

Since last century, carbon monoxide (CO) generally regarded as “silent killer” and life-threatening for living organisms because of its colourless, odourless and poisonous nature. Haldane explored the poisonous nature of CO can be exerted as car-boxy hemoglobin (COHb) through hemoglobin dissociation parameters

DNA Nanotechnology Engineered Vesicle for Mimicking Biomolecular Signaling

Bio-inspired strategy is kind of interesting to fabricate devices and perform dynamic operations [1]. Various devices have been made, such as airplane, radar and submarine. In life science, as the fundamental entity, million years’ evolution enables cell becomes the most successful functionality.

Safety of Using Rituximab Therapy During COVID-19 Pandemic

Our modern world is facing extraordinary circumstances while passing through a serious pandemic caused by the novel coronavirus (COVID-19) which may lead to multi-organ system failure & death. Bcell depletion could compromise antiviral immunity, which makes the safety of rituximab use in the COVID19 era unclear.

Deubiquitinase as Potential Targets for Cancer Immunotherapy

During the last few decades, immunotherapy is considered to be an important approach to help our immune system to fight various kinds of diseases, such as tumor. Sometimes, it works very well for some types of cancers, for example: bladder cancer, colorectal cancer, breast cancer and lymphoma.

Exploiting Nanotechnology to Target Viruses

Infectious diseases caused by microorganisms of the most varied natures and by viral entities cause millions of deaths every year. Around the world, viral infections have impacted civilizations’ circumstances since the earliest times, including the current panorama of the SARS-CoV-2 pandemic known as coronavirus disease in 2019 (COVID-19). In this sense, in the last century,

Acute Success and Long-term Follow-up of Catheter Ablation of Isthmus-dependent Atrial Flutter; A Comparison of 10 mm Tip Standard, 6 mm Tip Irrigated Radiofrequency, and Cryotherapy Catheters

Various catheter ablation technologies have evolved to improve the procedural success and safety of cavotricuspid isthmus (CTI) block. Numerous studies have compared the different energy types, catheter tip sizes, and energy settings.

Early Onset Fetal Growth Restriction: Does Path to Diagnosis Impact Outcomes and Pathology?

Objective: To evaluate demographics and outcomes of maternal-fetal pairs in early onset fetal growth restriction (FGR) requiring delivery prior to 34 weeks’ gestation based on ultrasound indication leading to diagnosis. Study Design: This is a descriptive study of maternal-fetal pairs with early FGR diagnosed prior to 30 weeks’ gestation and delivering between 22w0d and 34w0d under the care of Wake Forest University Perinatology 01/2012-12/2016.

Synthetic Lethal Drug Combinations Targeting Proteasome and Histone Deacetylase Inhibitors in TP₅₃-Mutated Cancers

Background: We have recently published SL-BioDP, a web resource for querying, exploration and visualization of potential synthetic lethal targets and possible synergistic drug combinations for 18 cancer types. Methods: From our predictive synthetic lethality model used in SL-BioDP, we inferred TP53 mutation lead to potential synergistic drug combination of Bortezomib and Vorinostat. Here we show, how to extrapolate the drug combination results by combining drug screening data from cancer cell lines and showed the potential synergy of the drug targets, proteasome, and histone deacetylase (HDAC) pathways respectively, for patient survival advantage.

Physiotherapy Research in a Danish University Hospital: A Retrospective Review, 2010-2018

Patients of all ages with motor disorders expect highquality assessments and evidence- based treatment [1]. In university hospitals, alongside medical training and treatment of patients, research [2] is an integral part of the skills for medical professionals e.g. doctors, nurses, occupational therapists and physiotherapists.

Role of the Gut Microbiome in the Modulation of Cancer Immunotherapy Response

The gut microbiome or gut flora is a vast community of microorganisms such as bacteria, viruses, protozoa, and fungi that inhabit the digestive tract of the human and other animals. In the human body, bacterial species colonize into the oral cavity, skin, vagina, and placenta, however, the largest population of microorganisms resides in the intestine. The majority of gut microbiota belong to the phyla Firmicutes, Bacteroidetes, Proteobacteria and Actinobacteria.

Current Issues of Novel Drug Versus Thrombosis as Main Cause of Death

Appropriate medicinal drugs can save life of any patientat risk with high mortality and morbidity. All ongoingcosts and benefits are covered mainly by the health insurance, the pharmaceutical, and alternative medicine industry.

Sentinel Lymph Node Biopsy after Neoadjuvant Chemotherapy for Breast Cancer

Breast cancer is the second most common cancer worldwide, affecting nearly one in eight women. Accurate cancer staging is essential for determining the patient’s prognosis and for choosing the appropriate treatment. The staging system most often used is the American Joint Committee on Cancer (AJCC) TNM system, where T refers to the size of the tumor, N refers to spread of the primary cancer to nearby lymph nodes, and M refers to the spread of metastasis to distant sites in the body.

Platelet Hyperactivity and Dysfunction in Diabetes and Cancer

However, the entire coagulation cascade is dysfunctional, in progressed chronic diabetes and cancer patients. Platelets (PLTs) in type 2 diabetic (DT2) involved in Thrombosis and Haemostasis (T&H) of individuals adhere to vascular endothelium and aggregate more voluntarily than those in healthy individuals, as are abnormalities in the microvascular and macrovascular circulations. However it is already known that the circulating PLTs are essential for T&H, inflammation growth factors delivery, regeneration; and knowledge of their function is fundamental to understanding the pathophysiology of vascular disease in diabetes and cancer-related diseases.

Safety and Efficacy of s-MOX Regimen in Patients with Colorectal Cancer Who Developed Cardiotoxicity Following Fluoropyrimidine Administration: A Case Series

Fluoropyrimidines compose the backbone of regimens to treat many common solid tumors, including gastrointestinal (GI), breast and head/neck. As we continue to use these agents routinely, recognition of rare but real toxicities, such as cardiotoxicity, has also improved. The treatment options for patients who have encountered fluoropyrimidine-induced cardiotoxicity are limited as many anti-angiogenic drugs also pose a cardiac risk.

Psychosocial Aspects of Drug Prescription: Recognizing These Phenomena to Improve the Quality of Clinical Practice

The psychosocial aspects of pharmacological prescription are the factors that intervene in ways of reacting of the doctor and the patient to the prescription of a drug, as well as the role of social structures that determine it. The role of psychosocial factors in pharmacologic treatment of patients remains unclear and is notably absent in the literature of the discipline of general medicine. Biological (specific) and psychosocial (nonspecific) effects of drugs are not simply additive, but interact with each other.

Journal of Nanotechnology and Nanomaterials

2025

Recommended Articles

About Scientific Archives