Journal of Clinical Haematology
Volume 2, Issue 1, p1-35
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
Isolated Kidney Infarct and Lupus Anticoagulant Positivity in a Young Patient with Mild SARS-CoV-2 Infection
The incidence of thromboembolic events in COVID-19 is reportedly higher in intensive care unit (ICU) patients (29.4%) as compared to non-ICU patients (11.5%), while data on thromboembolic events in non-hospitalized, self-limiting COVID-19 is unavailable. Renal infarction with COVID-19 has only been reported in three patients who had severe infection, multiple comorbidities, and/or immuno-compromised state post kidney transplantation. Since the onset of the SARS-CoV-2 pandemic, guidelines for the prophylaxis and treatment of COVID- 19-related hypercoagulability have only been focused on hospitalized patients. Concurrently, risk factors and management guidelines for thromboembolic events in mild COVID-19 have remained unidentified. In this report, we describe a case of a 38-year-old male–with no medical history pertinent to hypercoagulability–who developed an isolated renal infarction one week after being diagnosed with mild COVID-19.J Clin Haematol, 2021, Volume 2, Issue 1, p1-4 | DOI: 10.33696/haematology.2.021
Lower 24-Month Relative Survival among Black Patients with Non- Hodgkin’s Lymphoma: An Analysis of the SEER Data 1997-2015
Recent progress in the therapies used for patients with Non- Hodgkin’s lymphoma (NHL) has improved survival. In 2020, 77,240 people were diagnosed with NHL. Although it accounts for 4% of all cancers, the incidence has been reported to be decreasing in the last few years. About 26% of people will expire from NHL (15% males and 11% females).Non-Hodgkin lymphoma arises from the clonal expansion of B, T, and natural killer (NK) cells. There is a significant degree of heterogeneity in NHL and this is likely related to different degrees of differentiation and maturation of these cells. These hematological malignancies exhibit different tumor behavior and are responsive to different chemotherapy agents which impacts clinical outcomes. There are patients who can be cured with current regimens; however, subtypes such as indolent and some aggressive lymphomas remain incurable necessitating treatment with new therapies including immunotherapy, targeted therapy, CAR T cells, and hematopoietic stem cell transplant.J Clin Haematol, 2021, Volume 2, Issue 1, p5-13 | DOI: 10.33696/haematology.2.022
Impact of Early COVID-19 Advice and Guidelines on the Blood Supply in Low- and Middle-Income Countries
In March 2020, the Asian Association of Transfusion Medicine (AATM) took the initiative to support and guide the 20 member and 5 associate-member countries in their efforts to continue their blood supply with minimal interruption or shortages during the pandemic. Within two weeks, they published a guideline and an instructive Aide Mémoire, which were also communicated with the major international blood transfusion organizations, WHO and the EU. This was echoed by a rapid appearance of national and international guidance documents.J Clin Haematol, 2021, Volume 2, Issue 1, p14-17 | DOI: 10.33696/haematology.2.023
The Association of PRKRAP1 Pseudogene with Acute Lymphoblastic Leukemia Risk
Acute lymphoblastic leukemia (ALL) is the deterioration of the maturation period of lymphoblasts, and the uncontrolled excessive reproduction of the abnormal cells. In addition to gene rearrangements, chromosome number abormalities (Down syndrome, etc.), and genetic locations, being male, Caucasian ethnicity, having a sibling diagnosed with leukemia, exposure to radiation, having received chemotherapy or radiotherapy, and exposure to some toxins and chemical substances such as benzene may be counted as the ALL risk factors.J Clin Haematol, 2021, Volume 2, Issue 1, p18-23 | DOI: 10.33696/haematology.2.024
Pre-operative Intravenous Iron to Optimise Patients Before Cardiac Surgery
The World Health Organisation (WHO) defines anaemia as a haemoglobin (Hb) of less than 130 mg/mL in men and 120 mg/mL in non-pregnant women. Anaemia has a global prevalence of 25%. In patients presenting for surgery the prevalence can be as high as 40%. Anaemia can be acute or chronic; but becomes problematic when there are insufficient numbers of red blood cells to maintain physiological oxygen demand, the end result being compromised oxygen delivery.J Clin Haematol, 2021, Volume 2, Issue 1, p24-35 | DOI: 10.33696/haematology.2.025
Karyotypic Profile of Chronic Myeloid Leukemia in Patients Diagnosed at Tertiary Level in Afghanistan
Balanced translocation resulting in fusion of the Abelson gene (ABL1) from chromosome 9q34 with the breakpoint cluster region (BCR) gene on chromosome 22q11.2 is the pathognomonic molecular driver of CML. The resulting BCRABL 1 fusion gene is both the diagnostic as well as therapeutic target of CML. The first agent with tyrosine kinase inhibitor activity that was licenced in 2000 for treatment of CML patients, was Imatinib, gradually followed by multiple agents with higher efficacy.
COVID-19 Clinical Research
While the global COVID-19 pandemic has challenged the entire humanity and health systems, it also triggered researchers to urgently perform clinical trials to assess the safety and efficacy of many agents and modalities to combat COVID-19. As of April 22, over 650 clinical studies have been registered both in USA and internationally. Results from these studies are also coming at a brisk pace in this unprecedented emergency.
Therapeutic Values of Ketamine for COVID-19-Cared Patients: An Expert’s Point of View
Ketamine has long been used in the field of anesthesia . Its rapid and long-acting analgesic effects associated with its dissociative properties have also established its use in prehospital and emergency department patients.
A Bioinformatics Protocol for Rational Design of Peptide Vaccines and the COVID-19 Rampage
The currently ongoing coronavirus pandemic, the SARSCOV- 2, interchangeably referred to as the COVID-19 infection, has in a short span of time altered the ways and means of almost all of mankind. So strong has been its effect that all human activity ceased in one way or another for a considerable time, led to significant loss of life and economic drain of.
Prospective Evaluation of Effect of Metformin on Activation of AMP-activated Protein Kinase (AMPK) and Disease Control in a Sub-group Analysis of Patients with GI Malignancies
Observational studies have demonstrated association of metformin with reduced cancer incidence and mortality in multiple cancer types, including gastrointestinal (GI) malignancies. Anti-neoplastic effects of metformin are believed through many mechanisms including activation of AMP-activated protein kinase, which controls mammalian target of rapamycin (mTOR) growth regulatory pathway.
Angioimmunoblastic T cell Lymphoma Microenvironment
Angioimmunoblastic T cell lymphoma (AITL) is one of the most common T-cell lymphomas, second only to peripheral T-cell lymphoma not otherwise specified (PTCL-NOS). Initially AITL was considered a non-malignant lymphadenopathy with immune hyperactivation, nowadays being classified as a PTCL.
Lessons Learnt from COVID-19: How Can We Prepare for Another Pandemic?
Five months into the COVID-19 pandemic, the U.S. death toll from the virus has now surpassed 100,000 people. Many more cases remain nationwide, while an unknown number of patients currently harbor the virus asymptomatically. While health officials are now optimistic regarding the decline in prevalence and number of deaths due to COVID-19 and the possibility of a vaccine by the fall, we cannot lose sight of the bigger picture: the next pandemic.
Safety of Using Rituximab Therapy During COVID-19 Pandemic
Rituximab is a chimeric (20% rodent and 80% human) monoclonal antibody that binds to the CD20 antigen present on the cell surface and leads to depletion of mature B-cells [1,2]. It is the first approved monoclonal antibody to be used in the therapy of indolent B-cell non- Hodgkin’s lymphoma and chronic lymphocytic leukemia
Educators as Essential Workers in the Era of COVID-19: Applying Lessons from Disaster Recovery
In the article, “Mental Health Framework: Coronavirus pandemic in post-Katrina New Orleans” , Shervington and Richardson offer recommendations about how to anticipate and address disaster-related, trauma exposures associated with the coronavirus pandemic
How Well Do Hemodialysis Patients Respond to the BNT162b2 mRNA COVID-19 Vaccine?
In January 2020, the World Health Organization (WHO) classified COVID-19 to be a Public Health Emergency of International Concern and declared it a pandemic on March 11, 2020 . Over one hundred and eighty-five million people have been infected by SARS-CoV-2 and roughly four million have died worldwide so far
Reduced BCR Signaling and a Metabolic Shift Accompanies Malignant Progression of Follicular Lymphoma: A Lesson from Transcriptomics
Lymphoma represents the most common form of hematological malignancy in the developed world, accounting for 3.6% of all cancers and 55.6% of all blood cancers in Europe, with non-Hodgkin lymphomas (NHL) representing 90% of cases.
In silico Analysis for the Repurposing of Broad-spectrum Antiviral Drugs against Multiple Targets from SARS-CoV-2: A Molecular Docking and ADMET Approach
SARS-CoV-2 belongs to the genus Beta of the Coronaviridae family of enveloped single-stranded, positive-sense ribonucleic acid (RNA) with a genome length of 30,000bp. The virion is composed of various non-structural (RNA dependent RNA polymerase also known as RdRp) and structural proteins such as Spike (S), Nucleocapsid (N), Matrix (M), and Envelope (E) proteins.
Predicting COVID-19 Hospitalized Patients’ Outcome with Homocysteine
The COVID-19 pandemic has provoked a global, rapid increase of cases due to the high infectivity of the etiological agent, COVID-19 virus. In February 2021, over 110 million confirmed COVID-19 cases with 1 million deaths were reported worldwide (www.who.int).
Molecular Biology for BCR-ABL1 Quantification for Chronic Myeloid Leukemia Monitorization and Evaluation
Chronic Myeloid Leukemia (CML) is a clonal disorder originated by a pluripotent hematopoietic stem cell, which presents the translocation t(9;22) (q34;q11) in 90% of the cases.
Pseudothrombocytosis Due to Red Blood Cell Fragmentation in Haemoglobin-H Disease
Red cell membrane in patients with haemoglobin H (Hb-H) disease and other haemoglobinopathies is rigid and thus red blood cells are fragmented during passage through narrow capillary beds, especially through the splenic sinusoids and the liver [1,2]. These fragments are frequently seen in peripheral blood films.
Dexamethasone: The First Drug to be Shown to Decrease Mortality in Critically Ill Patients with COVID-19
The precise role of corticosteroids for treatment of coronavirus disease 2019 (COVID-19) is unclear due to lack of randomized trials.
How to Prevent Rehospitalization in Patients with COVID-19
Since December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) caused by 2019 Novel Coronavirus (2019-nCoV) has resulted in 89,000 cases of Corona Virus Disease 2019 (COVID-19), formerly known as Novel Coronavirus Pneumonia (NCP) in China, including 2,450 deaths.
Commentary on “Epigenetically Altered T Cells Contribute to Lupus Flares”
The recently published manuscript entitled “Epigenetically Altered T Cells Contribute to Lupus Flares” summarizes recent advances in our understanding of how the environment alters the immune system to cause flares of systemic lupus erythematosus (SLE) in genetically predisposed people, and why it affects women approximately 9 times more often than men
The Role of NETosis in Systemic Lupus Erythematosus
Systemic Lupus Erythematosus (SLE) is a devastating autoimmune disease that affects women to men at a ratio of 9:1 and is predominant in those of African ancestry. In SLE, the presence of autoantigens results in aberrant immune activation leading to systemic inflammation that predominantly affects the brain, kidneys, blood, and skin. Current guidelines recommend treatment with immunosuppressive drugs like prednisone, cyclophosphamide, azathioprine, and even some antimalarial drugs
Challenges Regarding the Management of Gynecological and Obstetric Complications in Women with Inherited Factor XIII Deficiency
The medical care of patients with inherited bleeding disorders requires a greater understanding and attention, especially in women who can be exposed to specific hemorrhagic complications such as menorrhagia or complications during pregnancies and deliveries.
Scientific Archives is a global publisher initiated with the mission of ensuring equal opportunity for accessing science to research community all over the world. Spreading research findings with great relevance to all channels without any barrier is our goal. We want to overcome the challenges of Open Access with ensured quality and transparency.