Archives of Nephrology and Renal Studies

With the advent of the direct oral anticoagulants (DOACs), patients requiring anticoagulation for common conditions such as atrial fibrillation and venous thromboembolism no longer need to worry about dietary restrictions or regular monitoring of the international normalized ratio which complicated warfarin treatment.

Chronic hypertension is present in 1-2% of pregnant women. Women with chronic hypertension are at an increased risk of maternal and perinatal complications when compared with normotensive women. It is not uncommon for the women with chronic hypertension to present first time during pregnancy and obstetricians are the first one to encounter them during antenatal checkup. Secondary hypertension is often unrecognised and misdiagnosed thus leading to improper treatment with significant risk to the mother and fetus. 

Diabetes mellitus is a common metabolic disorder that present with abnormal glucose metabolism. This metabolic disease is prevalent in many countries, worldwide. It is no doubt there might be a chance that diabetes mellitus might co-occur with other medical problems.

To date, only glucocorticoids have been shown to reduce mortality in COVID-19. Use of remdesivir was associated with reduced length of stay in hospitalized COVID-19 patients. A deadly second wave in Asian countries has caused increased demand and usage of remdesivir in these countries. However, there is limited data about its efficacy in patients with severe renal dysfunction or end-stage renal disease on dialysis.

Diabetes mellitus is one of the most common chronic diseases that affect people of all ages and races worldwide.

Pulmonary Arterial Hypertension (PAH) represents a rare but devastating disease due to small pulmonary arterial vessels remodelling and increased pulmonary vascular resistance leading to right ventricular dysfunction, right heart failure and death.

Aldosterone excess is known to worsen hypertension and kidney function. Three selective aldosterone synthase inhibitors (ASIs) were evaluated in 3 phase 2 trials. In the first study, the ASI baxdrostat 2 mg orally once daily decreased systolic blood pressure (SBP) by 11.0 mmHg compared with placebo after 12 weeks in patients with treatment-resistant hypertension. In the second study including patients with uncontrolled hypertension, placebo-corrected reduction in SBP with lorundrostat 50 mg once daily was 9.6 mmHg after 8 weeks.

Diabetes is one of the most common metabolic conditions that can significantly impair the overall quality of life. Diabetic nephropathy is a diabetes-associated renal damage condition and one of the most common diabetes-induced renal complications. The hyperglycaemia associated with diabetes is considered one of the key factors associated with the renal damage. The endocannabinoid system is a complex biological process involved in various physiological activities, while its impairment is directly associated with numerous pathological conditions as well.

Renalase, a newly discovered flavin-adenine dinucleotide-dependent amine oxidase released by the kidney, circulates in the blood and has an impact on heart function and systemic blood pressure. We conducted the research in Babylon from February to July of 2016. We collected 50 blood samples from patients with end stage renal disease admitted to Merjan Teaching Hospital in Babylon Province, Iraq. In addition to the control group (50 samples) of healthy people aged 11 to 80, all patients and control groups were from the same ethnic group (Arab).

Transcatheter mitral valve repairs have been utilized significantly more over the last decade to treat mitral valve regurgitation. Hyponatremia, the most common electrolyte abnormality in hospitalized patients, adversely impacts patient outcomes. However, the impact of hyponatremia on cardiovascular outcomes among TMVR patients remains to be explored.

Introduction: Hypertension (HTN) is a major public health issue and is both a cause and a common complication of chronic kidney disease (CKD). This study aimed to determine the prevalence of HTN and identify its associated factors in patients with advanced CKD in Parakou, Benin. Patients and Methods: A cross-sectional study was conducted in the Nephrology Department of the CHUD-B/A hospital from April 01, 2023, to August 31, 2023. We included all consenting patients aged 15 and over with stage 3 to 5 CKD. 

Mutations in a single TRPV6 allele trigger chronic pancreatitis while loss of both alleles is responsible for skeletal dysplasia in newborns. The latter clinical presentation is accompanied by elevated serum levels of the parathyroid hormone, a condition known as transient neonatal hyperparathyroidism (TNHP). In humans, TRPV6 is abundantly expressed in the primary fetal-maternal interface in the placenta, as well as in pancreatic acini and within a few exocrine glands including salivary and lacrimal glands.