Aug 08, 2019: Dr. Johanna Meléndez and team reported 2 unique cases of HIV positive patients with generalized lymphadenopathy and pancytopenia showing primary lymph node kaposi´s sarcoma

Researchers from Roosevelt Hospital at Guatemala present two unique cases in which two HIV positive patients with generalized lymphadenopathy and pancytopenia without any skin lesions were diagnosed with primary lymph node Kaposi´s Sarcoma after excisional biopsy of an inguinal lymph node. Kaposi’s Sarcoma (KS) is a malignant systemic disease that requires infection with human herpes virus 8 (HHV-8). This latest report confirms that the biopsy of selected lymph node in patients with primary lymph node Kaposi´s sarcoma has the same pathological result as in any other KS. Dr. Johanna Meléndez and team demonstrated histological evaluation of the surgical specimen which revealed spindle-shaped cells with extravasated erythrocytes typical of Kaposi’s sarcoma. A key finding from this study was the importance of Paclitaxel (a chemotherapy medication), which helps in the improvements in pain and swelling and produced hematological recovery in HIV positive patients.

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